Course catalogue doctoral education - VT24
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| Title | Nervous System Injury and Repair |
|---|---|
| Course number | 5595 |
| Programme | Neurovetenskap |
| Language | English |
| Credits | 1.5 |
| Date | 2024-02-05 -- 2024-02-09 | Responsible KI department | Institutionen för klinisk neurovetenskap |
| Specific entry requirements | Basic Neuroscience course or corresponding knowledge. The basic neuroscience course should include neuroanatomy, CNS cell-types and their functions, and some CNS injury/disorders. |
| Purpose of the course | The purpose of the course is for participants to gain broad knowledge concerning the biological consequences after injuries (e.g. trauma, stroke, surgery) to the nervous system (CNS/PNS). The course aims to provide an overview of the pathobiology that follows after injury, experimental models/methods, regenerative and non-regenerative features, species differences, treatment strategies, as well as clinical features and biomarkers. Importantly, the course intends for the participants to appreciate various research efforts and opportunities for nervous system repair, as well as providing a translational outlook on these topics. Hence, the participant will learn the fundamental features and topics associated to nervous system injury and repair.
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| Intended learning outcomes | The student should be able to:
1) Describe various injuries to the nervous system and its consequences to the neuronal networks and circuits 2) Give examples of, and put into context, the cellular and molecular pathobiological mechanisms that are initiated after an injury to either the central or peripheral nervous system. 3) Describe some distinct features of regeneration vs no regeneration in various circumstances and species. 4) Give examples of how to study injury and repair of the nerve system, including changes in neuronal networks and pathobiology. 5) Give example of repair/treatment strategies and diagnostic methods, as well as discuss some of the difficulties treating the CNS and potential hurdles in translation of treatments. |
| Contents of the course | The course will cover topics related to the consequences following injury to the nervous system, including the secondary injury, post-injury phases, and potential outcomes. This includes cellular and molecular events such as inflammation, reactive gliosis, CNS scarring (glial/fibrotic scarring), demyelination/remyelination, neuronal network reformation, and more. Moreover, we will cover how these events can be studied and what experimental models/methods are used. We will discuss and give examples of the possibilities for diagnostics and the reparative potential of different treatment strategies. Thus, we will cover and provide up-to-date information regarding both pre-clinical and clinical efforts and applications, including knowledge gaps. Students will participate in group sessions that will facilitate discussion regarding the above topics and there will be assignments focusing on specific aspects of nervous system injury and repair. |
| Teaching and learning activities | The course runs daytime for one week full-time with a mix of lectures by invited scientists. There will be group session and assignments, as well as individual studies. Participants will prepare and give oral presentations. Active participation that allows interaction between the PhD-students will be promoted. |
| Compulsory elements | In order to achieve the learning outcomes all participants are expected to be present the whole week. The group assignments, the oral presentations by the students and the following general discussion between all participants are compulsory. Students that are absent from these parts will have to individually submit a written presentation of the subject according to the instructions of the course organizer. |
| Examination | The examination part includes: the group assignments, short formative examination questions at the end of some of the days during the course week, the oral presentations by the students and the following general discussions between all participants. All students are individually assessed. |
| Literature and other teaching material | Recommended scientific articles and hand-outs will be made available well in advance of the start of the course. |
| Number of students | 8 - 16 |
| Selection of students | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date) |
| More information | 9-17 all days at campus KI Solna. |
| Additional course leader | |
| Latest course evaluation | Course evaluation report |
| Course responsible |
Jacob Kjell Institutionen för klinisk neurovetenskap jacob.kjell@ki.se |
| Contact person | - |
