Kurskatalog forskarutbildning - VT24

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Titel Clinical and Experimental Neuroimmunology
Kursnummer 3200
Program 1-Ingår i flera program
Språk Engelska
Antal högskolepoäng 1.5
Datum 2023-10-16 -- 2023-10-20
Kursansvarig institution Institutionen för klinisk neurovetenskap
Särskild behörighet
Kursens syfte The purpose of this course is to enable doctoral students and other participants to gain an understanding of the major neuroinflammatory diseases and the key players involved, including the interaction between the central nervous and immune systems. An additional purpose is that those who participate in the course learn to understand critical aspects of creating and using experimental systems to model neuroinflammatory diseases.
Kursens lärandemål After this course the students should be able to: (i) describe the basic clinical characteristics of the major neuroinflammatory diseases; Multiple Sclerosis (MS), Myasthenia Gravis (MG) Guillain-Barré Syndrome (GBS), and Narcolepsy, (ii) explain how to create experimental models for neuroinflammatory diseases in rats and mice, compare models and discuss their advantages and limitations, (iii) evaluate and interpret new findings and recent scientific papers in the field in relation to main previous findings and (iv) speculate on and discuss molecular mechanisms underlying neuroinflammatory disease and hypothesize how knowledge on these mechanisms can enable therapy and prevention.
Kursens innehåll The course includes an overview of clinical symptoms, signs, pathology, treatments and diagnostic criteria for the most important neuroimmunological diseases including MS, MG GBS/CIDP and Narcolepsy. Also included is an overview of experimental models of neuroimmunological diseases, with an emphasis on techniques for genetic analysis (designing and creating intercrosses, congenics, transgenics in rats and mice etc). Key molecular concepts in neuroinflammation are covered such as immune mechanisms (the blood-brain barrier (BBB), major cell players, MHC-TCR interaction, costimulation, chemoattraction) as well as key tissue degeneration/regeneration. Different techniques used to study neuroinflammation are discussed including imaging, high-throughput genotyping, expression analysis and proteomics.
Arbetsformer The course combines: (i) traditional lectures (usually in the morning), given by the experts in the field, (ii) presentation of diverse experimental models, (iii) a structured discussion in small groups to design an experimental model for one of the major neuroinflammatory diseases with a short presentation to the class, followed by the evaluation of strengths and weaknesses of an experimental model proposed by another group and (iv) an individual assignment followed by an interactive presentation/discussion on the last day. The assignment will preferably consist of a presentation of a high-impact scientific paper relevant to the student's own research topic, and that is of importance for the neuroimmunology field. Alternatively, experimental setting/ data as a part of ones own doctoral project may be presented.
Obligatoriska moment All lectures, demonstrations and group tasks are compulsory. Compensation for absence can be discussed with the course directors, and may involve literature reviews with written reports on the topic missed.
Examination Examination will be based on the groups assignment/discussion and the individual assignment, including the subsequent discussions (please see ""Teaching and learning activities"") and the feedback given to other students on their assignments. In their presentations, students should be able to comment on the design of their experimental model for one of the major neuroinflammatory diseases or article of choice in the context of the items described above under ""learning outcomes"". Guidelines for the preparation of the assignments will be sent out to the students two weeks before the start of the course.
Kurslitteratur och övriga läromedel Course literature will consist of lecture handouts and current scientific articles (original and reviews) handed out during the course.
Recommended reading:
Focus collection in Nature Reviews Neurology: https://www.nature.com/collections/gjjjhiejfd
Recommended book: Principles of Neural Science, Sixth Edition; Eric R. Kandel, Thomas M. Jessell, Steven A. Siegelbaum
Antal studenter 8 - 30
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
Övrig information This course is given jointly by the doctoral programmes Allergy, immunology and inflammation (Aii) and Neuroscience (Neuro). See: https://ki.se/en/staff/doctoral-programmes. Time: Monday-Friday, 9:00-17:00; Location: Center for Molecular Medicine (CMM), Karolinska University Hospital, Solna, building L8, lecture hall/seminar room and conference room.
Ytterligare kursledare Co-organizers: Milena Zeitelhofer Adzemovic and Pernilla Strid
Senaste kursvärdering Kursvärderingsrapport
Kursansvarig Manuel Zeitelhofer
Institutionen för medicinsk biokemi och biofysik

Manuel.Zeitelhofer@ki.se
Kontaktpersoner Pernilla Strid
Institutionen för klinisk neurovetenskap

Pernilla.Strid@ki.se


 Milena Zeitelhofer-Adzemovic
Institutionen för klinisk neurovetenskap

Milena.Zeitelhofer-Adzemovic@ki.se