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Titel | Overview course in Cancer Drug Discovery |
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Kursnummer | 5541 |
Program | Tumörbiologi och onkologi (FoTO) |
Språk | Engelska |
Antal högskolepoäng | 1.5 |
Datum | 2022-10-17 -- 2022-10-21 | Kursansvarig institution | Institutionen för onkologi-patologi |
Särskild behörighet | Students must have completed Basic course in tumor biology and oncology. |
Kursens syfte | This course describes the steps, processes and approaches needed for drug discovery with a focus on oncology. Through lectures and interactive workshops, the students will learn about current drug discovery techniques, from screening for hit discovery to the synthesis of the final drug candidate through lead optimization. Aspects of clinical testing and precision medicine will also be addressed.
In this five-day course, students will attend lectures by prominent scientists from academic and industry active in the fields of drug screening, drug library design and logistics, disease models, drug development, medicinal chemistry, image analysis, chemoinformatics, precision medicine, and clinical trials. The students will also participate in a group-based learning project to design their own screening strategy, and site-visits to drug discovery companies based in Stockholm, as well as the screening platform at SciLifeLab Chemical Biology Consortium Sweden. At the end of the course, the students should have a good overview and understanding of the drug discovery workflow in cancer research, allowing them to pinpoint potential career directions for their own scientific paths. |
Kursens lärandemål | At the end of the course the student is expected to be able to:
Knowledge and understanding -Describe, define and understand the different drug discovery approaches used in both academia and industry. -Familiarity of the drug discovery process through to clinical implementation. Competence and skills -Ability to describe the concepts and terminology of drug discovery in cancer. -Understanding the different screening strategies and the associated benefits and shortcomings. -Ability to describe and understand how a compound can become a drug and its clinical implications. Judgement and approach -Demonstrate the ability to understand the concepts of drug discovery. -Evaluate how a drug discovery campaign can be used to discover new anti-cancer drugs. -Evaluate how drug discovery techniques can be currently used in a clinical setting for precision medicine. |
Kursens innehåll | The main blocks of the course include:
Drug discovery in pharma and academia: a perspective -ChemoInformatics -Drug Library design -Model systems Drug discovery strategies -Target-based in vitro screens -Cell-based phenotypic screens -Virtual screens -High-throughput phenotypic screening -High content imaging -Image analysis -Multi-parametric analysis Target identification -Thermal Shift (CETSA and others) -CRISPR -Transcriptomics (cMap) -PISA Lead optimization and Medicinal chemistry -Journey from compound to drug -ADME and toxicity Clinical trials and patient stratification -Diagnostics -Drug repurposing in personalised cancer medicine Workshop: design your screening strategy to target one of the hallmarks of cancer. |
Arbetsformer | Lectures, workshops and site-visits. |
Obligatoriska moment | Attendance to all lectures and workshops is compulsory. Attendance will be compensated for using summaries of literature articles addressing the topics corresponding to the missed lectures. |
Examination | The examinations will consist in a written (2 pages) and short oral presentation of a mock drug discovery project that is well motivated in background of the current state of knowledge/lack of knowledge in the cancer research area of choice or their own scientific path. Each student should actively participate (ask questions or comment) the other students's presentations at the final session of the course. One needs to show that all intended learning outcomes are reached for a pass. |
Kurslitteratur och övriga läromedel | Required reading:
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674. doi:10.1016/j.cell.2011.02.013 (https://www.ncbi.nlm.nih.gov/pubmed/21376230) Swinney DC, Anthony J. How were new medicines discovered?. Nat Rev Drug Discov. 2011;10(7):507–519. Published 2011 Jun 24. doi:10.1038/nrd3480 (https://www.nature.com/articles/nrd3480) Hughes JP, Rees S, Kalindjian SB, Philpott KL. Principles of early drug discovery. Br J Pharmacol. 2011;162(6):1239–1249. doi:10.1111/j.1476-5381.2010.01127.x (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058157/) Recommended reading: Arrowsmith CH, Audia JE, Austin C, et al. The promise and peril of chemical probes. Nat Chem Biol. 2015;11(8):536–541. doi:10.1038/nchembio.1867 (https://www.nature.com/articles/nchembio.1867) Blagg J, Workman P. Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology . Cancer Cell. 2017;32(1):9–25. doi:10.1016/j.ccell.2017.06.005 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511331/) Boutros M, Heigwer F, Laufer C. Microscopy-Based High-Content Screening. Cell. 2015;163(6):1314–1325. doi:10.1016/j.cell.2015.11.007 (https://www.cell.com/cell/fulltext/S0092-8674(15)01487-7?rss=yes) Jones LH, Bunnage ME. Applications of chemogenomic library screening in drug discovery. Nat Rev Drug Discov. 2017;16(4):285–296. doi:10.1038/nrd.2016.244 (https://www.nature.com/articles/nrd.2016.244) Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 2009;8(7):567–578. doi:10.1038/nrd2876 (https://www.nature.com/articles/nrd2876) Horvath P, Aulner N, Bickle M, et al. Screening out irrelevant cell-based models of disease. Nat Rev Drug Discov. 2016;15(11):751–769. doi:10.1038/nrd.2016.175 (https://www.nature.com/articles/nrd.2016.175) |
Antal studenter | 8 - 25 |
Urval av studenter | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date) |
Övrig information | |
Ytterligare kursledare | Tom Erkers |
Senaste kursvärdering | Kursvärderingsrapport |
Kursansvarig |
Brinton Seashore-Ludlow Institutionen för onkologi-patologi brinton.seashore-ludlow@ki.se |
Kontaktpersoner |
Tom Erkers Institutionen för onkologi-patologi tom.erkers@ki.se |