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Titel Bioinformatics analysis of gene regulation in omics data and its applications to medical problems
Kursnummer 3027
Program Cellbiologi och genetik
Språk Engelska
Antal högskolepoäng 3.0
Noteringar Kursen uppfyller kraven för en allmänvetenskaplig kurs.
Datum 2020-02-27 -- 2020-03-11
Kursansvarig institution Institutionen för biovetenskaper och näringslära
Särskild behörighet
Kursens syfte To increase the understanding of the basic principles of bioinformatics and to gain practical skills in bioinformatics analysis of genomic sequencing data.
Kursens lärandemål After the completed course, the participants will be able to understand the principles and perform basic bioinformatics analysis of genomics sequencing data. The participants will be able to plan experimental designs and to critically evaluate the appropriateness of the different sequencing based omics methods and technologies for genome-wide gene regulation studies.
Kursens innehåll Principles of gene regulation in non-disease cases and dysregulation in diseases at individual locus level as well as on genome-wide level. Principles of sequencing based genomics technologies and corresponding bioinformatics data analysis. Concrete bioinformatics data analysis by the students of selected published projects.
Arbetsformer The course consists of preparatory work, lectures, discussion, seminars and hands-on bioinformatics analysis.
Obligatoriska moment The preparation is done in the first course week without the need to be present on-site. Week 2 consists of tasks, lectures, discussions, seminars and hands-on practicals. Both parts are compulsory. Absence has to be compensated for according to the instructions from the course leader.
Examination The students will be examined for all learning outcomes by their performance in (a) submitted replies to tasks given for course week 1, (b) discussions and quizzes during the course week 2, and (c) individual presentations at the last course day of their bioinformatics analysis results conducted during course week 2.
Kurslitteratur och övriga läromedel Recent articles and websites.
Antal studenter 15 - 20
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
Övrig information The first week of the course (2020-02-27 to 2020-03-04) is in the form of individual homework (distance course), as preparation for the second week of the course. Week 2 of the course (2020-03-05 to 2020-03-11) consists of tasks, lectures, discussions, seminars and hands-on practicals in Stockholm. The statistical language R will be used for the hands-on practical. It is recommended that participants have previous experiences with R. The course is given in collaboration with the RIKEN Center for Integrated Medical Sciences (RIKEN IMS, http://www.ims.riken.jp/english/). The course faculty consists of invited speakers from the RIKEN IMS and from Karolinska Institutet. The course takes place at Karolinska Institutet in Stockholm. The traveling and accommodation costs for participants from Japanese universities will not be covered by the course.
Ytterligare kursledare The course director is Dr. Carsten Daub from Karolinska Institutet and the co-director is Dr. Piero Carninci from RIKEN IMS.
Senaste kursvärdering Kursvärderingsrapport
Kursansvarig Carsten Daub
Institutionen för biovetenskaper och näringslära

Carsten.Daub@ki.se
Kontaktpersoner Matti Nikkola
Institutionen för cell- och molekylärbiologi

Matti.Nikkola@ki.se