Syllabus database for doctoral courses
-
Startpage
Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Protein struktur, funktion och sjukdom |
|---|---|
| English title | Protein Structure, Function and Disease |
| Course number | 5561 |
| Credits | 4.5 |
| Responsible KI department | Department of Biosciences and Nutrition |
| Specific entry requirements | Completed Master studies in the field of biochemistry, biotechnology, biomedicine, biophysics, chemical neuroscience or related subjects. |
| Grading | Passed /Not passed |
| Established by | The Committee for Doctoral Education |
| Established | 2022-03-08 |
| Purpose of the course | The course deals with the molecular properties of proteins concerning their molecular structure and implementation in biology as well as protein misfolding and the relation to neurodegenerative diseases. It covers the general architecture of proteins, the relation of structure to function and mechanisms of regulations of protein function. It includes recent insights into the molecular mechanisms of protein aggregation and the link to neurodegenerative diseases. Moreover, it gives an overview about recent developments within methods for protein structure and dynamics determination, in particular X-ray crystallography, electron microscopy and nuclear magnetic resonance. The course will also train the participants to prepare scientific presentations and critically assess research literature.
|
| Intended learning outcomes | At the end of the course the students are expected to be able to:
• Understand how protein architecture is related to protein function • Explain how protein dynamics, catalysis, binding sites and cofactors determine the protein structure-function relationship • Identify and discuss control mechanisms of protein function, including competitive binding and cooperativity of ligands, post-translational modification and enzyme reactions • Understand the principles and apply some tools for sequence alignment, homology modeling and structure prediction methods from protein sequence • Show up-to-date knowledge of the working principles for major methods for protein structure and dynamics determination as well as microscopic nucleation mechanisms underlying protein aggregation |
| Contents of the course | The course is divided into two parts.
The first part of the course is based on the course book “Protein Structure and Function” and related research articles and consists of: • Protein structure (from primary to quaternary structure, protein stability and protein flexibility, etc.) • From structure to function (binding sites, catalysis, cofactors, etc.) • Control of protein function (mechanisms of regulation, binding ligands, post-translational modifications, etc.) • Deriving protein function from sequence (sequence alignment, homology modeling, structure prediction, etc.) The second part is based on lectures from the course directors and from invited specialists in the field, including • Neurodegenerative disorders and protein misfolding • Molecular mechanisms of protein aggregation • Recent developments in protein structure and dynamics methods, including o X-ray crystallography o Electron microscopy o Nuclear magnetic resonance |
| Teaching and learning activities | The course consists of
• Student presentations of research articles related to Chapters in the course book. If suitable examples from the student’s own research can be included. • Questions for student presentations by students (two students are assigned as “opponents” for each presentation) and audience • Written tasks, including practical of bioinformatics tools, related to the content of the Chapters, which are handed in before each session • Presentations by several invited specialists of the field |
| Compulsory elements | Attendance of lectures, student presentations and exercise sessions is compulsory. Absence needs to be compensated for by a written task related to the lecture subject in agreement with the course director. Further, the students need to submit written tasks and perform one scientific presentation about a research article.
|
| Examination | The course content will be examined by written tasks as well as student presentations and oral examination of the topic by the course directors.
|
| Literature and other teaching material | Mandatory reading:
1. Gregory A Petsko, Dagmar Ringe Protein Structure and Function Oxford University Press Inc ISBN: 9780878936632 224 pages 2. Additional lecture material (will be provided) |
Course responsible |
Axel Abelein Department of Biosciences and Nutrition axel.abelein@ki.se |
| Contact person |
