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SYLLABI FOR DOCTORAL COURSES

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Swedish title Principer inom cellulär metabolism
English title Principles of cellular metabolism
Course number 2851
Credits 1.5
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2017-09-26
Purpose of the course The course is intended to give a solid theoretical foundation for studying cellular metabolism from a physical, quantitative perspective, enabling the student to critically approach literature in the field, and serving as a preparation for more specialized courses.
Intended learning outcomes After completing the course, the student should understand the principles underlying the organization of metabolic pathways in human cells; be able to critically evaluate literature and data on cellular metabolism; understand current methods for measuring cellular metabolism; and have a solid foundation to enable deeper study of metabolism independently.
Contents of the course The fundamental organization of cellular metabolism; physical constraints on metabolism; important building blocks of metabolic pathways and their properties; major metabolites in human cells; carbohydrate metabolism; amino acid metabolism; nucleotide metabolism; lipid metabolism (briefly); principles of enzyme catalysis and bioenergetics of metabolic pathways; genomic organization of enzymes; properties of metabolic networks; metabolic fluxes and flux balance analysis; catabolism during nutrient starvation; anabolism in proliferating cells; methods for measuring metabolism, in particular isotope tracing; experimental considerations when studying metabolism in cell systems.
Teaching and learning activities The course will utilize a problem-based learning model with ""flipped classroom"" techniques, interactive seminars, problem-solving in groups, oral presentations, and individual assignments. Computer labs are included to study metabolic networks and metabolic flux analysis.
Compulsory elements Presence on seminars and computer labs is mandatory. Absence must be compensated for by a written resume.
Examination Knowledge is assessed by performance in connection to seminars (comments, questions, answers), performance on computer labs, and an individual home assignment (problem solving / essay) with a short individual oral presentation.
Literature and other teaching material Berg, Tymoczko, Stryer: Biochemistry (6th ed or later). Scientific articles and other handouts. Tutorials and worked examples on metabolic networks and metabolic flux analysis.
Course responsible Roland Nilsson
Institutionen för medicin, Solna


roland.nilsson@ki.se
Contact person