Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Intracellulär proteolys I: Ubiquitin/proteasome-systemet i hälsa och sjukdom |
|---|---|
| English title | Intracellular proteolysis I: The ubiquitin/proteasome system in health and disease |
| Course number | 2899 |
| Credits | 1.5 |
| Responsible KI department | Institutionen för cell- och molekylärbiologi |
| Specific entry requirements | |
| Grading | Passed /Not passed |
| Established by | The Board of Doctoral Education |
| Established | 2016-03-22 |
| Purpose of the course | To increase the understanding of the integrated role that intracellular proteolysis plays in normal and pathological cellular processes, and how this can be investigated. |
| Intended learning outcomes | When the students have passed the course, they will be able to describe the molecular mechanism of protein degradation by the ubiquitin/proteasome system and how this relates to human diseases such as cancer, neurodegeneration and immunological disorders. The students will also be able to design experiments for studying the ubiquitin/proteasome system and to critically evaluate data obtained with these techniques. |
| Contents of the course | This course covers the molecular mechanism underlying the ubiquitin/proteasome system and its role in human diseases. Extra attention will be paid to experimental methods to study the ubiquitin/proteasome system. We will discuss the relation of ubiquitin/proteasome system to human diseases, in particular to cancer, neurodegeneration and immunological disorders. We will also pay attention to its central role in intracellular proteolysis and cross-talk with other proteolytic systems. |
| Teaching and learning activities | The learning modes used in the course include lectures, research seminars and a mini-symposium. Every student will present a recent publication in a journal club. Students will have lunch meetings with the invited speakers and will also be encouraged to actively participate in the course. There will be ample time for discussions after the lectures and research seminars. |
| Compulsory elements | The lectures, seminars and journal club presentations are compulsory. Compensation according to the instructions of the course director. |
| Examination | Examination is based on the journal club presentation and discussions. Every student will be at one occasion presenting a paper that has been selected by the organizers and at another occasion will be an opponent when a fellow student is presenting a selected paper. The students' performance at these two occasions combined with active participation in the course will be the basis for the final assessment. |
| Literature and other teaching material | Recent original and review articles in the field of the ubiquitin/proteasome system in health and disease. | Course responsible |
Matti Nikkola Institutionen för cell- och molekylärbiologi Matti.Nikkola@ki.se |
| Contact person |
Linda Lindell Institutionen för cell- och molekylärbiologi 08-524 872 90 0703822909 linda.lindell@ki.se Solnavägen 9 171 77 Stockholm |
