Syllabus database for doctoral courses

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Swedish title Epigenetiska Metoder
English title Epigenetic Methods
Course number 2764
Credits 1.5
Responsible KI department Institutionen för klinisk neurovetenskap
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2014-11-05
Purpose of the course
Intended learning outcomes After the course the student should be able to describe basic and advanced epigenetic principles and theory. Further, the student shall have sufficient knowledge of current methods to design and perform an epigenetic study. At the end of the course the student should be able to critically choose the right clinical material and methodology to answer/investigate a special epigenetic question of interest.
Contents of the course The course will cover the basics to understand epigenetic principles and methods. The focus will be on demonstrating and explaining current methods in the field, e.g. bisulfite pyro-sequencing, LUMA, MeDIP, Illumina 450k bead chip, hydroxymethylcytosine analysis and ChIP. Some methods will include hand-on practice.
Teaching and learning activities The course will start with introductory ""cathedral"" lectures on basic epigenetic principles. Special emphasis will be on principles for choice of methods and clinical samples, e.g. target tissue vs. blood. This will be followed by theory on selected epigenetic methods, and ""hands-on"" laboratory work in groups. During the fifth day there will be an interactive exercise regarding how to select a proper epigenetic approach, followed by presentation of group work/lab.
Compulsory elements All parts are mandatory. Absence from a lecture or discussion may be compensated by a written assignment, on agreement with the course leader. Every student will be individually assessed.
Examination Interactive excercise to discuss how to plan and organize an epigenetic study. Oral presentation of group work/lab.
Literature and other teaching material Relevant publications covering the topic will be handed out by lecturers.
Course responsible Malin Almgren
Institutionen för klinisk neurovetenskap

Contact person Malin Almgren
Institutionen för klinisk neurovetenskap

Louise Sjöholm
Institutionen för klinisk neurovetenskap