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Title Basic Course in Tumor Biology and Oncology
Course number 3112
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 3.0
Date 2023-09-25 -- 2023-10-06
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements
Purpose of the course This course is an introduction to modern cancer research and oncology. The course is recommended to all PhD students within the field of basic and clinical cancer research. The purpose of the course is to give a general overview of CLINICAL ONCOLOGY and the molecular mechanisms that promote the carcinogenic transformation. The overall aim of the course is THEREFORE to form a bridge between pre-clinical and clinical aspects of tumor biology and oncology for PhD students and to provide the students a BROAD understanding of cancer. We aim to link the basic tumor biology concepts with the main principles of diagnosis and treatment of cancer patients in line with the modern concept of translational and personalised cancer medicine.


Intended learning outcomes Upon completion of the course the students will be able to;
• Explain the concepts of modern cancer treatments in relation to basic cancer biology.
•Understand concepts of clinical cancer management, personalized cancer medicine and outcome evaluation in cancer.
• Reflect on and discuss the concept of clinical trials, the role of translational research and the challenges thereof.
• Reflect on and discuss the most important problems that need to be solved in cancer.
• Reflect on and discuss future goals in cancer prevention, diagnostics and therapy.
Contents of the course The course will describe the causes as well as the consequences of the transformation of a normal cell into its malignant counterpart, in order to create an understanding of cancer --from molecule to patient--, eventually also discussing the management and treatment of cancer. The topics of the course include genetics, the cell cycle, apoptosis, immunology, diagnosis and treatment, all topics presented from the cancer perspective.
There will be focus on a few malignant diseases, described in more detail serving as models for basic concepts of Tumor Biology and Oncology, including molecular genetics, curative treatment and palliative care, psychosocial aspects of cancer, ethics and epidemiology.

Teaching and learning activities The course consists of introductory lectures on cancer management and concepts in cancer, and specific lectures including cancer biology and clinical applications. Reading and group discussions. Group seminars and presentations All students will be offered a possibility to visit the the clinic and meet cancer patients.
Compulsory elements Full time during two consecutive weeks. All lectures and teaching activities are mandatory.Single missed occasions will have to be compensated by other relevant activities after discussion with the course leaders.
Examination Written individual examination and oral presentation of the group assignment based on the concept of cancer and tumor biology. Each student will be individually assessed.

Literature and other teaching material Recommended literature:
-Hallmarks of Cancer: The Next Generation, Hanahan and Weinberg; Cell, March 2011;
-Hallmarks of Cancer: New Dimensions, Douglas Hanahan; Cancer Discovery, January 2022
-The biology of cancer 2nd edition, Weinberg, Robert A; Garland Science, Taylor and Francis group, 2014;
Number of students 12 - 30
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course will be held at KI campus and at Karolinska University hospital.
Additional course leader Daria Glaessgen
Latest course evaluation Course evaluation report
Course responsible Hanna Eriksson
Institutionen för onkologi-patologi

Hanna.Eriksson.4@ki.se
Contact person Daria Glaessgen
Institutionen för onkologi-patologi
08-51773128
daria.glaessgen@ki.se