Course catalogue doctoral education - VT24

  • Application can be done between 2023-10-16 and 2023-11-15
Application closed
Title Researching the Human Gastrointestinal Tract, Liver and Pancreas – An Overview
Course number 5696
Programme Metabolism and Endocrinology
Language English
Credits 1.5
Date 2023-11-20 -- 2023-11-24
Responsible KI department Department of Medicine, Huddinge
Specific entry requirements
Purpose of the course This course will increase the interest in and knowledge about how to study the gastrointestinal tract, which includes the liver and the pancreas, for clinical and translational research purposes. The course aims to give an overview of anatomy, function, and common diseases of the GI tract, how they are linked to metabolic features and alterations, and how the disease panorama can be studied in a translational context. The course also highlights the possibilities and challenges how to perform sampling, tissue handling, biobanking and registration according to good clinical and laboratory practice.
Intended learning outcomes 1) To describe the normal anatomy and function of the gastrointestinal tract.
2) To relate the disease panorama of the gastrointestinal tract, including brief knowledge of etiologies and pathogenesis, to the most important current research questions.
3) To discriminate between and motivate the choice of the various possibilities for sampling from the gastrointestinal tract for morphologic, metabolic, immunologic, microbiotic, and genetic research purposes as well as for using samples for different in vitro techniques.
4) To reflect upon and discuss issues of creating your own sample collection in a biobank, including ethical and legal aspects and required registries.
Contents of the course The course will present an overview of the basic anatomy and physiology of the gastrointestinal tract, the metabolism of the liver and the pancreas, and the disease panorama of the gastrointestinal tract. Different aspects of non-alcoholic fatty liver disease, inflammatory bowel disease, autoimmune liver and pancreatic diseases, IgG4 systemic disease and pathological conditions of the small bowel, including post-surgical metabolic complications and sarcopenia will be discussed. Various autoimmune and metabolic aspects of disease will be highlighted. A workshop will be dedicated to sampling techniques, resources and pitfalls, including endoscopic and parenchymatous biopsies, tissue handling and storage, and how to create your own sample collection in a biobank, including legal and ethical aspects. The role of the microbiome for metabolic and gastrointestinal diseases will be covered in a workshop and hot topics in microbiota research discussed in the journal club format.
Teaching and learning activities The course will be based upon:
1) Lectures given by experts
2) Interactive workshops highlighting key topics
3) Literature reviews with journal clubs
4) Case-based discussions focusing on clinical cases linked to research questions.
Compulsory elements Workshops, journal clubs, oral group assignments with case-based discussions and the MCQ examination.
Examination Multiple choice questions covering the normal anatomy and function of the gastrointestinal tract, the gastrointestinal disease panorama, metabolic and immunological aspects, sarcopenia and the role of the microbiome (learning objectives 1 and 2)
Oral assignments with supervised case-based discussions in smaller groups linking patient cases to research questions (learning objectives 3 and 4)
Literature and other teaching material Recommended literature:

• Gastroenterologi och hepatologi. Eds. Lindberg, Nyhlin. Studentlitteratur 2016. ISBN 9789144093406 (Swedish).
• Gastroenterology Clinical Focus: High yield GI and hepatology review- for Boards and Practice - 3rd edition
• Greenberger's CURRENT Diagnosis & Treatment Gastroenterology, Hepatology, & Endoscopy, Fourth Edition (Current Medical Diagnosis & Treatment in Gastroenterology)

Review articles
• Borowitz SM. The epidemiology of inflammatory bowel disease: Clues to pathogenesis? Front Pediatr. 2023 Jan 17;10:1103713. doi: 10.3389/fped.2022.1103713. PMID: 36733765
• Gines, P., et al. Liver cirrhosis. Lancet 2021; 398(10308): 1359-1376.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course starts on Monday at 09.30 and ends on Friday at 13.00 at Campus Flemingsberg.
Additional course leader Greger Lindberg and Miroslav Vujasinovic
Latest course evaluation Not available
Course responsible Per Stål
Department of Medicine, Huddinge
Contact person Greger Lindberg
Institutionen för medicin, Huddinge

Miroslav Vujasinovic
Institutionen för medicin, Huddinge