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Title Cellular Signalling
Course number 3049
Programme Utveckling och regeneration (DevReg)
Language English
Credits 1.5
Date 2023-10-16 -- 2023-10-20
Responsible KI department Institutionen för klinisk vetenskap, intervention och teknik
Specific entry requirements
Purpose of the course The purpose of the course is to enable the student to acquire a broad view of various signalling pathways and to identify common themes on protein-protein and protein-lipid interactions in human disease. The students shall learn how signal transduction occurs through a highly regulated cascade of events inside cells. The student will be given the opportunity to learn to identify and reflect on the knowledge (general methodology and theoretical concepts) gained with the benefit for the student’s own research.
Intended learning outcomes After completed course, the student should be able to:
- show adequate knowledge on general concepts in the field of signal transduction
- discuss common methods and techniques in the field of signal transduction
- apply some of the conceptual knowledge in his/her own research project(s)
- choose relevant scientific questions, analysis methods and design a general plan to study this
Contents of the course The course brings up current aspects in cellular signalling and the developments in methodology that has cultivated the understanding of the function of the different signalling pathways in various model systems and diseases. The course will cover major aspects of protein and lipid kinases, heterotrimeric G-proteins, small GTPases, cytokine and growth hormone receptors, secondary messengers, transcriptional regulation and signal transduction in cell-specific responses to stimuli. The course will cover the molecular basis of certain diseases related to the abrogation of signalling pathways.
Teaching and learning activities On-campus lectures or live webinars by invited lecturers within the field. Student-focused activities to facilitate interaction and discussions on additional new topics and resources to retrieve information about a particular issue within the field of signal transduction. Self-studies and home assignment to prepare for oral examination.
Compulsory elements All lectures and activity moments are compulsory, missing lectures must be compensated by written résumé, while activity moments should be taken again in the next course occasion.
Examination Oral presentation on how concepts and methods/techniques in the field of signal transduction is, or could be, integrated into own research project. The presentation should clearly represent the knowledge gained during the course. One peer will be assigned as a critical friend to review the proposal. Oral presentation is compulsory, and it is essential to be an active participant in the follow-up discussions. It must be shown that all the intended learning outcomes of the course are achieved.
Literature and other teaching material Recommended literature:

Up-to-date review articles covering the lecture topics and/or the subject will be provided by the lecturers.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course will be given as on-site lectures at Campus Flemingsberg or interactive webinar lectures on Monday 16th of October to Thursday 19th of October 2023, between approximately 9 am to 4 pm. Time for self-studies and mandatory assignments will be scheduled. The examination seminar will be on Friday 20th of October.
Additional course leader
Latest course evaluation Course evaluation report
Course responsible Anna Witasp
Institutionen för klinisk vetenskap, intervention och teknik

Anna.Witasp@ki.se
Contact person Thomas Ebert
Institutionen för klinisk vetenskap, intervention och teknik

thomas.ebert@ki.se