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Titel Antigen Presentation and T Cell Activation
Kursnummer 2363
Program Allergi, immunologi och inflammation (Aii)
Språk Engelska
Antal högskolepoäng 1.5
Datum 2023-05-22 -- 2023-05-26
Kursansvarig institution Institutionen för onkologi-patologi
Särskild behörighet Basic immunology course, or otherwise have attained the same level of previous knowledge.
Kursens syfte This course will provide an overview of antigen presentation and T cell activation.
This course is suitable for PhD students with basic immunology knowledge who want to deepen their knowledge in important aspects of various lymphocyte subsets biology.
Kursens lärandemål - Describe and compare different types of antigen capture and processing, antigen presentation pathways, i.e. MHC class I & II, MR1 and CD1 system, peptide/lipid/glycolipid presentation, as well as the main T cell subsets and invariant lymphocytes.

- Identify gaps of knowledge about T lymphocyte activation, differentiation, antigen-presentation.

- Formulate a research question (including experimental plan) related to lymphocyte activation in steady state, disease, or cell therapy.
Kursens innehåll The following will be covered during the course:
Thorough walk-through of the antigen presentation pathways, both MHC class I and II, upstream and downstream of TCR activation.
The CD1 system, presentation of lipids, glycolipids, MR1 presentation and MAIT cell activation will be discussed.
Manipulation of T cell activation by checkpoint inhibitors, T cell exhaustion, the impact of tumor micro-environment, and practical applications such as immunotherapy, will also be covered.
Arbetsformer The course will be based on lectures, as well as time for questions and discussions.
In addition, work (in small groups) will enable the students to gain deeper knowledge in a specific area of interest.
The students are also given literature (see below) in order to prepare for the lectures and discussions.
Obligatoriska moment All lectures and group sessions are considered mandatory.
Missed events should be compensated for with a written report on the subject in accordance with the indications of the course organizer.
Examination To pass the course, the student has to show that the learning outcomes have been reached.
The students will be assessed with a group project presented in a written report, along with individual oral presentations.
The focus of the examination is gain of knowledge rather than test of knowledge.
Kurslitteratur och övriga läromedel Review articles and selected articles relevant to the lectures (invited speakers will also be asked to suggest papers), will be distributed during or prior to the course.
Examples:
- T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol. 2015;33:169-200. Rossjohn et al.
- The burgeoning family of unconventional T cells. Nat Immunol. 2015; 16(11):1114-23.Godfrey DI et al.
- Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61.Malissen B.
-Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.
Cancer Cell. 2017;31(3):311-325. Anderson KG et al.
Antal studenter 15 - 20
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant’s doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date), 3) basic immunology knowledge
Övrig information
Ytterligare kursledare
Senaste kursvärdering Kursvärderingsrapport
Kursansvarig Isabelle Magalhaes
Institutionen för klinisk vetenskap, intervention och teknik

Isabelle.Magalhaes@ki.se
Kontaktpersoner Isabelle Magalhaes
Institutionen för klinisk vetenskap, intervention och teknik

Isabelle.Magalhaes@ki.se