Course catalogue doctoral education - HT22

    Startpage
  • Ansökan kan ske mellan 2022-04-19 och 2022-05-16
Application closed
Print
Title Vascular Cell Biology
Course number 5560
Programme Kardiovaskulär forskning
Language English
Credits 3.0
Notes A Laboratory Animal Science course.

Date 2022-09-26 -- 2022-10-07
Responsible KI department Institutionen för molekylär medicin och kirurgi
Specific entry requirements Function A course: Carrying out minor procedures in rodents
Purpose of the course The objective of the course is to build up knowledge in the field of cardiovascular biology and disease using translational approaches. More specifically, the course provides an overview of the healthy and diseased vessel wall from the cellular and molecular perspective, including vascular development, biomechanics, blood flow and role of inflammation, lipid metabolism and smooth muscle cells. The course is designed to lay a solid foundation for the student commitment to basic, clinical, and translational cardiovascular research utilizing the most advanced technologies and expertise in the field. Through team work and joint presentations/discussions, students should increase their skills for collaborative networking, scientific presentation and communication to peers and to the public.
Intended learning outcomes Knowledge and understanding
- At the basic level students should be able to account for the various cell types and extracellular matrix components in the vessel wall, and critically review/discuss the potential cellular transdifferentiations in pathological conditions relevant to cardiovascular disease.
- They should be able to interpret the complex interactions among the different components, biomechanical and systemic influences within the vessel wall, and use it to explain the causality in the development of vascular disease.

Competence and skills
- By conducting laboratory projects during the course, students should be able to make a synthesis of the theoretical and practical knowledge and envision how that knowledge could be applicable in their own research projects.
- They should be able to discuss and compare state-of-the-art laboratory, translational and animal techniques applied for specific questions in this research area.

Judgement and approach
- Students should be able to demonstrate awareness of the ethical perspectives related to the biobanking and animal research, which will be incorporated and discussed during the course.
- They should be able to demonstrate insight into the possibilities and limitations of research, its role in society and the responsibility of the individual for how it is used.
Contents of the course The course will provide a theoretical and practical introduction to the basic cell types, extracellular components and their transformations present in the healthy and diseased vascular wall. Focus will also be on the signaling and basic biological process of cell activation, migration, proliferation and turnover involved in the vessel wall homeostasis during vascular development (arteriogenesis, angiogenesis), as well as the main vascular pathologies and vascular remodeling during injury and healing reactions. The impact of vessel biomechanics and components from the systemic blood flow on cell plasticity will also be covered.
Teaching and learning activities The learning methods in this course include both individual and group studies, exemplified through literature reading, journal club discussions and practical workshops related to the intended learning outcomes. Seminars with expert lecturers from KI and externally invited, will initiate and enhance the learning process. A practical laboratory project, where the students will test relevant methods for vascular research (in vitro, in situ and in vivo) and produce their own results, will be integrated. Course leaders will serve as facilitators for discussions, promote networking and collaboration skills during team work.
Compulsory elements The course is work-intensive. Presence is strongly recommended during the whole course, but is compulsory during group work, practical experimental tasks and examination. Absence is allowed in exceptional circumstances only and will have to be compensated with a written assignment in agreement with the course leader.
Examination All learning outcomes of the course must be reached to pass the course. Every participant will be individually assessed and examination will be based on several formats:

i) oral presentations of assigned group work. Time for group work will be designated during the whole course where teams prepare a presentation based on the experimental project they have designed and results they produced during laboratory work, supervised by the seminar leaders.

ii) participation during journal club discussion among the teams (evaluation of methods, results, discussion, etc.) facilitated by the seminar leaders.
Literature and other teaching material Lecturers and course organisers will recommend suitable research articles for optional individual studies one week prior to the course start. Recent literature, lectures and other information will be provided timely in the Canvas learning platform of the course. Examples of literature are given below:
1. Dennis Wolf, Klaus Ley. Immunity and Inflammation in Atherosclerosis. Circ Res. 2019 Jan 18;124(2):315-327.
2. Herbert SP, Stainier DY. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol. 2011
3. Ashish Misra, Rajan Rehan, Alexander Lin, Sanjay Patel, Edward A Fisher. Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2022 Feb 3;ATVBAHA121316093.
4. Gemma L Basatemur, Helle F Jørgensen, Murray C H Clarke, Martin R Bennett, Ziad Mallat. Vascular smooth muscle cells in atherosclerosis. Nat Rev Cardiol 2019 Dec;16(12):727-744.
5. Peter Libby. The changing landscape of atherosclerosis. Nature. 2021 Apr;592(7855):524-533.
Number of students 10 - 30
Selection of students The course is popular and if there are more applicants that the course can admit, priority will be given based on the: 1) relevance of the course plan for the student's project and 2) start date for doctoral studies (written motivation needed)
More information The course in Vascular Cell Biology has been given for over 20 years in different formats. The course is work intensive and will encompass classical lectures, mini-symposium, journal club discussions and laboratory placements for group work. The course will also be open for several MSc Biomedicine students on each occasion.
Additional course leader
Latest course evaluation Not available
Course responsible Ljubica Matic
Institutionen för molekylär medicin och kirurgi

ljubica.matic@ki.se
Contact person Joy Roy
Institutionen för molekylär medicin och kirurgi

Joy.Roy@ki.se


Ljubica Matic
Institutionen för molekylär medicin och kirurgi

ljubica.matic@ki.se