Course catalogue doctoral education - VT22

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Title Overview of Endocrinology – Aspects of Physiology, Cell and Molecular Biology
Course number 5529
Programme Metabolism och endokrinologi
Language English
Credits 3.0
Date 2022-03-28 -- 2022-04-08
Responsible KI department Institutionen för laboratoriemedicin
Specific entry requirements
Purpose of the course The purpose of the course is to enable doctoral students, and post-docs to obtain an in-depth understanding of the physiological, cellular and molecular mechanisms of hormone action in tissues in health and disease. To demonstrate understanding of the endocrine science studied and practised, students are required to write a scientific report. This is to give students experience in writing professional reports for a future career in science, where the ultimate aim is to publish research findings in order to share them with the wider scientific community. An additional emphasis will be placed on how state-of-the art methodologies have been utilised to further our knowledge of endocrine signalling.
Intended learning outcomes After successfully completing this course, students should have obtained a fundamental knowledge of molecular endocrinology and acquired the following abilities:
1. to construct pathways of the endocrine systems that link control and production of hormones in specific tissues with the actions of these hormones in their respective target organs;
2. to explain the mechanisms by which peptide and steroid hormones activate their receptors to provoke their biological effects;
3. to comprehend how the actions of hormones are involved in both health and disease;
4. to develop an in-depth comprehensive knowledge of endocrinology from a physiological, cellular, and molecular perspective.
Contents of the course This course will cover a selection of current topics involved in hormone signalling at an organ, tissue, cellular and molecular level from receptor interaction to gene response including receptor structure and function interactions with their hormone, second messengers, transcriptional regulation and autocrine and paracrine feedback signalling pathways. The course will emphasise the critical understanding of how hormones act at the molecular level and why their signalling pathways synergise or antagonise each other under normal and pathological physiological conditions. Knowledge of fundamental endocrinology: anatomy and physiology will provide foundational knowledge to complement current topics in endocrinology to exemplify the concepts of the course such as neuroendocrine signalling, metabolic disease, ageing, reproductive determination, exercise medicine and environmental medicine. To develop our in-depth comprehensive knowledge of endocrinology from a physiological, cellular, and molecular perspective the course will additionally cover current methodologies applied in research.
Teaching and learning activities The course will be distance learning-based comprising of lectures and interactive seminars exposing students to fundamental endocrine concepts, current topic seminars to exemplify concepts, and interactive student-led seminars and discussions to allow the students an opportunity to utilise conceptual knowledge. Additional quizzes will complement lectures to reinforce learning objectives.
Compulsory elements The students are expected to be present at all lectures and seminars. They are expected to actively participate in discussions. Missed sessions may be replaced by written tasks adapted to the situation.
Examination Each student will be assigned a written scientific report in endocrinology that is to be concerned with the many complexities of endocrine systems at the submolecular, molecular, cellular or organismal levels of analysis. The report is to be a concise overview of recent advances in a specified area and should present a balanced view of recent work. (Learning outcomes 1-4).
Literature and other teaching material Recommended reading Textbooks 1. Molecular Endocrinology, Editor Patricia Joseph-Bravo, 2006, Research Signpost. 2. Molecular Endocrinology 3rd Edition, Editor Franklyn F. Bolander, 2005, Elsevier Academic Press. 3. Fundamentals of Anatomy & Physiology 11th Edition, Editor Frederic H Martini, Judi L. Nath, Edwin F. Bartholomew, 2011, Pearson Education. Only specific chapters will be used from each textbook. Research article: articles will be provided to students prior to course start date.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant’s doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course was previously given the number 5282, as shown in the course evaluation report. The course will be distance learning-based comprising of lectures and interactive seminars.
Additional course leader John Flanagan
Latest course evaluation Course evaluation report
Course responsible Amarjit Saini
Institutionen för laboratoriemedicin

amarjit.saini@ki.se
Contact person John Flanagan
Institutionen för laboratoriemedicin
0704816995
john.flanagan@ki.se

CMM, L8:01
Andrology and Molecular Endocrinology Units
171 76
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