Course catalogue doctoral education - HT20

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Application closed
Title Gender/sex aspects in biomedical research
Course number 2387
Programme X- No longer used - Development Biology and Cellular Signaling (DECS)
Language English
Credits 1.5
Date 2011-05-23 -- 2011-05-27
Responsible KI department Department for Clinical Science, Intervention and Technology
Specific entry requirements
Intended learning outcomes After the course: 1. Students will be able to distinguish between the terms sex and gender. 2. Students will be able to evaluate the suitability of the design and analysis of preclinical and clinical research studies (e.g. their PhD project) to identify and quantify potential of sex and gender differences. 3. Students will be able to illustrate the scientific basis of known sex and gender differences. 4. Students will be able to identify known sex and gender differences with regard to diseases, and differences in response to or effects of drugs and other medical interventions in the treatment and management of these conditions.
Contents of the course The course is for both preclinical and doctoral students embarking upon the doctoral education in medical science, and those who wish to ""catch up"" on recent knowledge gains about the difference between men and women in both health and disease. We shall discuss some basic methodologies, theories and cellular biology, which will be considered in the relation to clinically relevant topics important for gender medicine. Several diseases of public health concern have already been identified. Those include cardiovascular diseases, lung diseases, neuropsychiatric disorders, steroid metabolism disorders as well as inflammatory and autoimmune diseases. Moreover pharmacological aspects as well as health economical issues will be considered in each of those conditions. Finally, further exploration of experimental models that could help to broaden our understanding of the disease process pertinent to the defined sex will be discussed.
Teaching and learning activities The course includes comprehensive lectures that describe most important topics relevant for the course. Each lecturer will be asked to provide 3 questions that should be strictly referred to the subject treated during the presentation in order to demonstrate the level of students comprehension in the examination. These questions will be used during final examination. Moreover, at the end of each the lecturer, the course organizer together with lecture will initiate the whole group discussion on the key message of the topic to enhance the learning process and for critical assessment of acquired knowledge and attitudes. Based on the student¿s background and scientific interest, buzz groups will be organized for project work in respect to topics selected by course organizer. The experience at individual scientific level will be promoted in order to implement in the group work. A final around table session will serve as a part of the final examination, at which projects will be introduced by each group and questioned by others. The course organizer and and the other tutors will assist during individual group work for project planning etc.
Compulsory elements All lectures are obligatory. Special reasons for absence can be discussed, and absence from specific lectures will be compensated through oral examination of the lecture's content by the course teachers.
Examination Oral presentation and a round table discussion on a topic introduced by course leader for a group work. Moreover, a written examination will be performed to answer questions prepared by each lecturer and the course organizer.
Literature and other teaching material Literature of importance: (please note that literature provided is based on several topics relevant for the course and as suggested for group work on different topics)Klinge I. Gender perspectives in European research. Pharmacol Res. 2008Sep-Oct;58(3-4):183-9. Epub 2008 Aug 6. Review.Klinge I. Bringing gender expertise to biomedical and health-related research.Gend Med. 2007;4 Suppl B:S59-63.Savic I, Lindström P. PET and MRI show differences in cerebral asymmetry andfunctional connectivity between homo- and heterosexual subjects. Proc Natl AcadSci U S A. 2008 Jul 8;105(27):9403-8.Huang, A. and G. Kaley (2004). ¿Gender-specific regulation of cardiovascular function: estrogen as key player.¿ Microcirculation 11(1): 9-38.Orshal JM, Khalil RA. 2004. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol 286: R233-49.Vitale C, Mendelsohn ME, Rosano GM. Gender differences in the cardiovasculareffect of sex hormones. Nat Rev Cardiol. 2009 Aug;6(8):532-42.Jensen-Jarolim E, Untersmayr E. Gender-medicine aspects in allergology.Allergy. 2008 May;63(5):610-5. Review.Legato MJ, Gelzer A, Goland R, Ebner SA, Rajan S, Villagra V, Kosowski M;Writing Group for The Partnership for Gender-Specific Medicine. Gender-specificcare of the patient with diabetes: review and recommendations. Gend Med. 2006Jun;3(2):131-58. Review.Kautzky-Willer A, Handisurya A. Metabolic diseases and associatedcomplications: sex and gender matter! Eur J Clin Invest. 2009 Aug;39(8):631-48.Epub 2009 Jun 3.Arain FA, Kuniyoshi FH, Abdalrhim AD, Miller VM. Sex/Gender Medicine. Circ J. 2009 Sep 4.Greaves LJ, Hemsing NJ. Sex, gender, and secondhand smoke policies:implications for disadvantaged women. Am J Prev Med. 2009 Aug;37(2 Suppl):S131-7.Holdcroft A. Integrating the dimensions of sex and gender into basic lifesciences research: methodologic and ethical issues. Gend Med. 2007;4 SupplB:S64-74. Review.Franconi F, Seghieri G, Canu S, Straface E, Campesi I, Malorni W. Are theavailable experimental models of type 2 diabetes appropriate for a genderperspective? Pharmacol Res. 2008 Jan;57(1):6-18. Epub 2007 Dec 23. Review. Phillips SP. Measuring the health effects of gender. J Epidemiol CommunityHealth. 2008 Apr;62(4):368-71. Review.Hankins C. Gender, sex, and HIV: how well are we addressing the imbalance?Curr Opin HIV AIDS. 2008 Jul;3(4):514-20.
Number of students 12 - 25
Selection of students Priority will be given to doctoral students undergoing doctoral eduation with particular focus on sex/gender aspects in biomedical reseach
More information The course will be held at karolinska University hospital-Huddinge campus
Additional course leader
Latest course evaluation Not available
Course responsible Karolina Kublickiene
Department for Clinical Science, Intervention and Technology

Karolinska Universitetssjukhus-Huddinge campus
Kvinnokliniken K-57
Contact person -