Course catalogue doctoral education - HT21

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Title Diabetes and Cardiovascular Disease
Course number 5310
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Date 2021-12-06 -- 2021-12-10
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements Undergraduate study in medicine or biomedicine
Purpose of the course To provide an overview of diabetes epidemiology, pathophysiology and treatment options in a cardiovascular perspective, with emphases on up-to-date therapeutic strategies, key findings of major clinical trials, and major challenges of future clinical managements and research. This includes the management of diabetes in the broad spectrum of cardiovascular disease as well as understanding and interpretation of large cardiovascular outcome trials of new glucose-lowering agents. Gaps in knowledge will be emphasized in order to create ideas for future clinical research in the field.
Intended learning outcomes The participants should, after the course, be able to:
1. show a good insight in the pathophysiological mechanisms linking diabetes to cardiovascular disease
2. know how to appropriately screen for and diagnose diabetes and pre-diabetes
3. perform cardiovascular risk stratification of patients with diabetes
4. understand the prognostic influence of diabetes on cardiovascular diseases
5. show an insight in preventive measures for diabetes and cardiovascular disease
6. know and interpret results of recent, large cardiovascular outcome trials on glucose-lowering drugs
7. understand some of the gaps in knowledge in the relation between diabetes and cardiovascular disease

Contents of the course Lectures/Seminars on the following topics:
- Epidemiological aspects of the combination of diabetes and cardiovascular disease
- Screening of diabetes and pre-diabetes in different populations
- Cardiovascular risk assessment in people with glucose perturbations
- Mechanisms of cardiovascular disease in diabetes: biomarkers, epigenetics, insulin resistance and microvascular disease
- Multifactorial management of people with diabetes and cardiovascular disease through lifestyle interventions and pharmacological treatment
- Cardiovascular outcome trials on glucose-lowering agents and their effects on atherosclerotic cardiovascular disease, heart failure and kidney disease
- Proposed mechanisms of cardioprotection by means of cardioprotective glucose-lowering agents
- Patient-centered care and management of complications
- Learning activities through interactive polls and clinical case presentations
Teaching and learning activities Lectures/Seminars with international lecturers and guideline experts
Debates about clinical issues
Clinical case presentations and discussion with interactive polls
Group work
Presentation and discussion of assigned group work
Compulsory elements The course participants should attend no less than 75% of the scheduled contents of the course. The participants must actively involve in the preparation of group work and attend the sections of their respective group work and presentation/discussion.
Absence from these sections cannot be compensated for.
Examination In collaboration with other course participants, to prepare and present a written synopsis of a study protocol on topics given by the faculty members.
Multiple choice questions and quizzes will be integrated in the different sessions of the course.
To pass the course the course participant must be able to show that all intended learning outcomes of the course are achieved.

Literature and other teaching material 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD.
Cosentino F et al.; ESC Scientific Document Group. Eur Heart J. 2020 Jan 7;41(2):255-323. doi: 10.1093/eurheartj/ehz486.

The organizers will provide course participants with electronic handouts/teaching materials from all lectures.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information Zoom. Day 1 09.00 – 12.00 – Lectures 13.00-16.30 - Group work Day 2 09.00 – 12.00 – Lectures 13.00-16.30 - Group work Day 3 09.00 – 12.00 – Lectures + interactive case presentations 13.00-16.30 - Group work Day 4 09.00 – 12.00 Lectures + Group work presentations Day 5 09.00 – 12.00 Group work presentations
Additional course leader Giulia Ferrannini Giulia.ferrannini@ki.se, Lars Rydén lars.ryden@ki.se, Anna Norhammar anna.norhammar@ki.se
Latest course evaluation Not available
Course responsible Linda Mellbin
Institutionen för medicin, Solna

Linda.Mellbin@ki.se
Contact person Nailin Li
Institutionen för medicin, Solna
08-51773996
Nailin.Li@ki.se

Clinical Pharmacology Unit
Karolinska University Hospital-Solna
17176
Stockholm