Course catalogue doctoral education - VT22

  • Application can be done between 2021-10-15 and 2021-11-15
Application closed
Title Thrombosis and Hemostasis, from Mechanisms to Therapies
Course number 3238
Programme Cardiovascular Research
Language English
Credits 3.0
Date 2021-11-08 -- 2021-11-19
Responsible KI department Department of Medicine, Solna
Specific entry requirements
Purpose of the course The course aims to bring doctoral students in-depth knowledge of thrombosis and hemostasis, to elucidate the links between molecular mechanisms and clinical disorders, to introduce current advances and future directions of thrombosis research, as well as to enhance the abilities for research question identifying and research design. The course is designed for the students who work with basic and clinical aspects of hemostasis, thrombosis and cardiovascular research.
Intended learning outcomes The concept from bench to bed side and back will be reinforced at all levels. Therefore, at the end of the course the students should be able to:
1. Describe the molecular and cellular mechanisms of hemostasis and thrombosis, as well as the dynamic processes of primary hemostasis, secondary hemostasis, and thrombosis.
2. Explain the mechanisms underlying bleeding and thrombotic disorders.
3. Have a good understanding of current anticoagulant and antiplatelet therapies, and obtain a clear view of the challenges of future anticoagulant and antiplatelet drug developments.
4. Apply current knowledge of thrombosis and hemostasis into future research design and to formulate new treatment strategies.
5. Sharpen the sense of critical appreciation of research literature, and strengthen their ability to develop new research concepts through critical reading and reflecting.
Contents of the course The following aspects of hemostasis and thrombosis will be discussed:
biochemistry of the blood clotting system; cell-cell and cell-protein interactions in the cardiovascular
system in relation to thrombosis and bleeding disorders; cross-talks of the clotting system with
inflammation, host defense and complement systems; diagnosis of bleeding and thrombotic disorders;
therapeutic strategies to fight thrombosis and bleeding with the emphasis placed on new pharmacological
concepts. In light of the new knowledge conveyed in the course, the emphasis will be laid on critical review of the literature, research question identification, and independent research design.
Teaching and learning activities Seminars
Group work
Online learning and group work on research design
Presentation of papers related to the key lectures
Compulsory elements To participate in the lectures, group work and presentation of the group work is compulsory. The students
who have missed the group work sessions can book extra session time within 4 weeks to compensate the
absence. Absence in lectures should be compensated for in accordance with the course director.
Examination Presentation of a paper related to key lectures
Research project design and reciprocal review between the work groups.
Multiple-choice test.
Literature and other teaching material The course will provide organised handouts from all lectures.
Recommended textbook for reference: Marder VJ, Aird WC, Bennett JS, Schulman S, White GC. Hemostasis and Thrombosis: basic
principles and clinical practice. Philadelphia, Lippincott Williams & Wilkins; 6th edition.
Number of students 8 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant’s doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The doctoral course Thrombosis and Haemostasis has been active at KI for more than 20 years, previously with the course number 2484. The course has been extended into two-week full time format with 3 HEC credits, which was much appreciated by the course participants. The extension allows the course to reinforce, apart from in-depth understanding of coagulation, thrombosis and haemostasis and their links to multiple clinical settings through course lectures (40%), the training on research competence and independence through online learning and individual/group work (60%). The latter includes critical review and presentation of research literature, research question identification, research project design, as well as reciprocal review and criticism of project project design. The second week of the course will be individual work on research literature review and research project design. A mentor is assigned for each course participant to evaluate and comment on the individual research project design. The course has been well appreciated by previous course participants as indicated by the course evaluation report (link below).
Additional course leader Doc Angela Silveira, email:
Latest course evaluation Course evaluation report
Course responsible Nailin Li
Department of Medicine, Solna

Clinical Pharmacology Unit
Karolinska University Hospital-Solna
Contact person Angela Silveira
Institutionen för medicin, Solna