Course catalogue doctoral education - HT21

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Title Basic Immunology
Course number 3187
Programme Allergy, immunology and inflammation (Aii)
Language English
Credits 3.0
Date 2021-09-06 -- 2021-09-24
Responsible KI department Department of Clinical Neuroscience
Specific entry requirements Knowledge in basic cell biology
Purpose of the course To give doctoral students the possibility to acquire a solid knowledge and understanding of fundamental principles in immunology. All other courses in the doctoral education program Aii (Allergy, immunology and inflammation) assume that students have taken the Basic Immunology course, or otherwise have attained the same level of previous knowledge and understanding.
Intended learning outcomes To be able to:
- Explain the basic principles of innate and adaptive immunity and how different components of the immune system cooperate.
- Describe and compare principles of immune-related diseases in a clinical perspective.
- Apply knowledge gained on the function of the immune system to propose an experimental project in immunology in the form of a written assignment, that will be discussed in pairs.
- Review a chosen immune cell type/process/disease, which will be presented as a group project.
Contents of the course The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmune and allergic diseases or transplantation.
Part 1: An overview of the immune system, T cells, B cells, Antigen presenting cells, Innate lymphoid cells, Innate vs adaptive immune responses.
Part 2: Immune defence against bacterial and viral infections, Primary immunodeficiencies, Autoimmune disease, Allergy, Vaccination, Clinical Immunology, Transplantation, Tumour Immunology. Questions and discussions. Presentation of projects.
Teaching and learning activities The course consists of lectures and seminars arranged during mornings five days per week. In the afternoon, students are assigned for reading to prepare for the next day’s topics as well as project work, further reading, meeting with mentors and a written assignment.
Course literature will be available on the course platform in advance of the course start and will be the basis for active discussion during the lectures. We will run exercises and immunological quizzes connected to the different parts of the course, so that the student will be able to digest the relatively big material.
On the last day of the course the project work will be presented orally.
Compulsory elements All activities included in the course are compulsory. Absence needs to be compensated for in agreement with the course director.
Examination Each student will be examined on the project work and the written assignment, as well as its contributions during the discussions. The project work will be evaluated by the group project mentor and by the course organizers during the oral presentations of the work. The individual written assignment is evaluated by the course organizers and will be discussed in pairs.
Literature and other teaching material Mandatory literature:
Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai: Basic Immunology: Functions and Disorders of the Immune System. Latest edition. (Elsevier – Health Sciences Edition).
Lecture handouts uploaded to the course website. Scientific review articles proposed by group project mentors.
Number of students 20 - 35
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course is divided into two sessions with 5 mornings of lectures each, September 6th to 10th (Monday to Friday) and September 20th to 24th (Monday to Friday). The afternoons will be dedicated to individual and group learning activities. Group presentation will be given on Friday September 24th. Teachers include specialists in different fields of immunology including both basic and clinical researchers. This course has previously been given with number 5229. The course will take place at CMM (Karolinska Institutet, Solna) and/or through Zoom, following the university's recommendations.
Additional course leader andre.ortlieb@ki.se
Latest course evaluation Course evaluation report
Course responsible Nicolas Ruffin
Department of Clinical Neuroscience

nicolas.ruffin@ki.se
Contact person -