Course catalogue doctoral education - HT21

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Title Research on personalized/precision cancer medicine (PCM)
Course number 2919
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2021-10-04 -- 2021-10-08
Responsible KI department Institutionen för mikrobiologi, tumör- och cellbiologi
Specific entry requirements
Purpose of the course The course will provide to the students the basic principles of personalized cancer medicine (PCM). It will focus on the need to combine new diagnostic tools such as omics, molecular pathology and imaging for tailor-made treatment to stratified or even individual patients. The need for development of multidisciplinary teams - to manage translational research - and core infrastructures will be emphasized. Participants will also learn about early clinical trials and biomarker discovery.
Intended learning outcomes After completion of the course the student will be able to:

- Define the principle of PCM
- Define the concept of molecular diagnostics
- Understand the place of HTP-omics methods in future cancer diagnostics
- Understand the role of modern imaging in PCM
- Describe the concept of early clinical trials
- Discuss the development of new and useful biomarkers
- Identify the technical tools and platforms that are required to develop such a multidisciplinary and target treatment for cancer patients
Contents of the course There will be lectures on molecular diagnostics, High-ThroughPut (HTP) omics, the SciLife platforms, modern imaging in clinical diagnostics, bioinformatics of PCM, early clinical trials and biobanking. Project work in small teams will focus on identification of new targets for treatment and biomarker discovery.
Teaching and learning activities The course will include a series of learning activities, including introductory and comprehensive
lectures/seminars, project work in groups, thematic discussions and student's presentations.
Compulsory elements Attendance to all the activities of the course are mandatory. Absence from mandatory parts of the course will have to be compensated by other relevant activities after discussion with the course leaders.
Examination The course assignment will consist of individual presentations of the solution to a research issue, based on the course topics and project work. One or two students will be appointed as reviewer(s) for each presentation to provide peer feedback for the presenter, in line with concept of formative assignment.

The course organizers will lead the examination and be responsible for summative individual assessment.
Literature and other teaching material Selection of recommended recently published research papers on the topic.
Number of students 20 - 30
Selection of students Twenty slots are reserved for the Clinical Cancer Research school NatiOn. Remaining ten slots will be offered based on the relevance of this course for the applicants docotoral project and the time since registration for PhD-studies.
More information Fulltime 9.00 - 16.00 every weekday. If possible lectures in Biomedicum and CCK-building, otherwise via Zoom as much as possible (due to to the COVID pandemic).
Additional course leader Claes Karlsson, Assoc prof, Hematology, Karolinska University Hospital Michele Masucci, MTC Päivi Östling, Oncology-Pathology and SciLife lab
Latest course evaluation Course evaluation report
Course responsible Ingemar Ernberg
Institutionen för mikrobiologi, tumör- och cellbiologi
+46852486262
Ingemar.Ernberg@ki.se

Box 280, Karolinska Institutet

17177
Stockholm
Contact person -