Course catalogue doctoral education - HT21

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Title Clinical achievements of reproductive medicine
Course number 2291
Programme Development and regeneration (DevReg)
Language English
Credits 1.5
Date 2021-09-06 -- 2021-09-10
Responsible KI department Department for Clinical Science, Intervention and Technology
Specific entry requirements
Purpose of the course The purpose of the course is to enable doctoral students to obtain a basic understanding of the biological processes involved in human reproduction. Experts in the field will provide with a fresh overview of clinical and pre-clinical research aiming at development of novel treatment possibilities but also discussing their current limitations.
Intended learning outcomes The learning outcomes of this course are that at the conclusion of this course students should be able to show a comprehensive view of key factors involved in reproductive biology and the processes involved in fertilization and implantation. Additionally, at the end of the course students will be able to perform a critical assessment of reported achievements on reproductive medicine and their current clinical possibilities and limitations.
Contents of the course Contents:

Biology of the gametes, fertilization and early embryo development
Normal and pathological implantation, early pregnancy loss, ectopic pregnancy, repeated miscarriage
In vitro spermatogenesis and oocyte maturation
Clinical investigation and therapeutic approach on female and male infertility
Genetics in infertility
Gonadal dysgenesia
Stem cells research
Assisted reproduction techniques (ART)
In vitro systems and cultures
Cloning. Somatic cell nuclear transfer
Clinical aspects of fertility preservation
Cryobiology systems for fertility preservation
Pre-implantation genetic diagnosis
Epigenetics in assisted reproduction
Experimental reproductive tissue transplantation procedures:
-ovarian and testicular tissue transplantation
-transplantation of the uterus
Teaching and learning activities Lectures, seminars/discussions and laboratory demonstrations.
Compulsory elements All teaching activities, including the laboratory sessions, the lectures and the assessments, are obligatory.
In case of not attendance to the activities, students should produce a literature work related with the subject of the missing activity upon agreement with the course organizer.
Examination Written examination and general group discussion of relevant parts of the examination.
Literature and other teaching material Recommended literature:

Textbook of Assisted Reproductive Techniques, Fourth Edition. David K. Gardner, Ariel Weissman, Colin M. Howles, Zeev Shoham. Informa, 2012.

Clinical Gynecologic Endocrinology and Infertility. Marc A. Fritz and Leon Speroff. Wolters Kluwer, 2010.

Infertility; Julius Hreinsson, Lars Hamberger, Thorir Hardarson, Studentlitteratur, 2005

New micromanipulative techniques in reproductive biology. Thesis dissertation, Karolinska Institutet. José Inzunza
Stockholm, 2003 (Stockholm: Karolinska University Press).

Rodriguez-Wallberg KA, Oktay K. Fertility preservation during cancer treatment: clinical guidelines. Cancer management and research, 2014 Mar 4;6:105-117.
Number of students 8 - 14
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course will be held in lecture rooms at Karolinska University hospital.
Additional course leader Jose Inzunza.
Latest course evaluation Course evaluation report
Course responsible Kenny Rodriguez-wallberg
Department of Oncology-Pathology
0858580000
kenny.rodriguez-wallberg@ki.se

Reproduktionsmedicin
Karolinska Universitetssjukhuset Huddinge
141 86
Stockholm
Contact person Cecilia Gotherstrom
Institutionen för klinisk vetenskap, intervention och teknik
08-58581487
Cecilia.Gotherstrom@ki.se

Klinisk Immunologi F79
Karolinska Universitetssjukhuset Huddinge
14186
Stockholm


Jose Inzunza
Institutionen för biovetenskaper och näringslära
08-585 850 93
Jose.Inzunza@ki.se

Hälsovägen 7, Novum

141 86
Stockholm


Karolina Kublickiene
Institutionen för klinisk vetenskap, intervention och teknik
0735930988
Karolina.Kublickiene@ki.se

Karolinska Universitetssjukhus-Huddinge campus
Njurmedicin
14186
Stockholm


Kenny Rodriguez-wallberg
Institutionen för onkologi-patologi
0858580000
kenny.rodriguez-wallberg@ki.se

Reproduktionsmedicin
Karolinska Universitetssjukhuset Huddinge
141 86
Stockholm