Kurskatalog forskarutbildning - HT21

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Titel Genomics for Biomedical Scientists: Handle Your Gene Expression Data
Kursnummer 3230
Program Cellbiologi och genetik
Språk Engelska
Antal högskolepoäng 3.0
Datum 2021-09-20 -- 2021-10-01
Kursansvarig institution Institutionen för mikrobiologi, tumör- och cellbiologi
Särskild behörighet
Kursens syfte The biomedical field has experienced a revolution thanks to the development of the massive parallel sequencing technologies. We can now obtain the complete genetic information of a patient in a few days at low costs. However, there is a gap between the application of classical molecular biology tools and the full use of the current genomic and computational approaches. To bridge this gap, the course is designed to give students an introduction to genomic approaches in gene regulation. The emphasis is that the students learn to apply genomic tools in their research without prior knowledge in computational biology. The students will also be made aware of ethical aspects in relation to technical progress.
Kursens lärandemål At the end of the course the student should be able to:
- Understand the crosstalk across the different levels of gene expression regulation, with special emphasis on chromatin organization, polymerase activity and RNA biology.
- Know the principles of high-throughput technologies applied to the study of gene expression, their advantages and limitations.
- Get a deeper understanding about investigating the dynamics of chromatin and gene regulation, and how deregulation of such states contributes to human diseases.
- Design genome-wide experiments for studying the transcriptome and chromatin state, and to critically evaluate results obtained with those approaches.
- Use common bioinformatics tools to analyse ChIP-Seq and RNA-Seq experiments.
- Make use of publicly available genome-wide databases and publications to complement their own research
Kursens innehåll The course covers the use of genome-wide approaches for the study of gene expression regulation and how these approaches have become key for biomedical research.
Particular attention will be paid to the understanding of advantages and limitations of those approaches, and applications to the study of human disease. The course will include both lectures and hands-on data analysis session, and provide the students tools to successfully navigate through the jungle of public available genome-wide datasets.
Arbetsformer Prior knowledge of programming is not required. The learning activities used in the course include lectures, practical training in data analysis, group discussions and problem-based learning activities. The students will be able to use gene expression data analysis software during the course. Students will be grouped in learning groups and present the results of their analysis of a preselected dataset from a recent publication in form of an oral presentation as well as design and develop a research project in which they apply what they have learned into their own ongoing research. Students will also be encouraged to actively participate in the course during the quiz and Q&A (question and answer) sessions. There will be substantial time for practising and discussing after the lectures.
Obligatoriska moment Students will be asked to describe a (e.g. their own) research problem prior to the course. The seminars, group discussions and presentations are compulsory. Absence cannot be compensated for.
Examination The students will be examined for all learning outcomes. The examination is based on:
- The student's contribution to the discussions during the course.
- The performance during the bioinformatic hands-on sessions.
- The student's individual contribution to the analysis and presentation at the last day of the course.
Kurslitteratur och övriga läromedel Literature will consist of recent research articles and online documentation of genomic tools. Those documents will be provided to students as PDF files prior to the course start.
Antal studenter 8 - 16
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
Övrig information The course most likely takes place at SciLifeLab in Solna (alternatively at Biomedicum in Solna). In the case that physical attendance is not recommended due to the SARS-CoV-2 pandemic, the course will be given online. The course will provide theoretical training combined with hands-on training. Part of the practical training can be performed remotely. Students are encouraged (but it is not obligatory) to work on their own RNAseq and ChIPseq data during the course.
Ytterligare kursledare Claudia Kutter Department of Microbiology, Tumor and Cell Biology claudia.kutter@ki.se
Senaste kursvärdering Kursvärderingsrapport
Kursansvarig Vicente Pelechano Garcia
Institutionen för mikrobiologi, tumör- och cellbiologi

vicente.pelechano.garcia@ki.se
Kontaktpersoner Vicente Pelechano Garcia
Institutionen för mikrobiologi, tumör- och cellbiologi

vicente.pelechano.garcia@ki.se


Claudia Kutter
Institutionen för mikrobiologi, tumör- och cellbiologi

claudia.kutter@ki.se