Course catalogue doctoral education - VT21

    Startpage
  • Ansökan kan ske mellan 2020-10-15 och 2020-11-16
Login or register to be able to apply this course

Print
Title Genomic Instability – for better or worse
Course number 5278
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2021-05-17 -- 2021-05-21
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements
Purpose of the course The course aims at providing the students with a comprehensive overview of Genome instability and its role in cancer development and progression. Genome Instability can on one hand be beneficial, creating possibility for natural selection during evolution. On the other hand, it can lead to severe consequences when the level of genomic alterations causes development of Cancer. Mutations and other deviations of DNA can be the consequence of inefficient DNA repair processes or alternatively, through genotoxic stress due to transcription, replication and chromatin modification processes causing DNA repair overload.

The students will at the end of the course have become acquainted with the DNA damage response and the different mechanisms involved in sensing, tolerating and repairing DNA damage and how this is exploited in cancer treatment. The student will gain a deeper understanding of how the DNA damage response connects to different cellular responses such as chromatin remodeling and epigenetics, as well as transcription, replication, cell cycle progression and apoptosis. Possibilities for design of anti-cancer treatment both with regards to DNA damaging chemo- and radiotherapy as well as emerging treatments targeting key players in the DNA damage response (targeted therapies) will be discussed and applied to the students own research projects.
Intended learning outcomes After passing the course, students will:
- have gained a comprehensive overview of genome instability and its role in cancer development and progression
- be able to discuss and explain different mechanisms involved in sensing, tolerating and repairing DNA damage and how this is exploited in cancer treatment
- understand the mechanism of action of DNA damaging inducing anti-cancer treatments and drugs targeting the DNA damage response
- be able to describe and understand state-of-the-art strategies for targeting the DNA damage response in cancer
- have gained knowledge about different molecular biology assays to study DNA repair and replication in cells and how this can be applied in their own research
- be able to understand and theorize about how the DNA damage response connects to different cellular responses such as chromatin remodeling and epigenetics, as well as transcription, replication, cell cycle progression and apoptosis and apply this knowledge in their own research projects
Contents of the course The course will cover the topics stated in the learning outcomes.
Teaching and learning activities The course consists of lectures and seminary by experts in their fields and group exercises such as journal clubs. To promote active learning, lectures and seminars are followed by discussions between the students and the speakers and the students will apply knowledge from the course in their own research projects in the examination.
Compulsory elements Attending the lectures, seminars group exercises and the examination seminar are compulsory. Absence can be compensated by other activities after discussion with the course leader.
Examination To pass the course the students must show that they have reached the learning outcomes of the course. The course assignment will consist of:
1) an individual oral presentation about integrating topics from the course in the students’ own research projects in line with the intended learning outcomes of the course.
2) the students are expected to ask questions on each others presentations and be able to discuss and answer questions from fellow students and course leader in line with the intended learning outcomes of the course.
Literature and other teaching material The students will be provided in advance with relevant literature (review articles, original publications). Teaching material will also be handed out during the course.
Number of students 8 - 30
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The students will be provided in advance with relevant literature (review articles, original publications).Teaching material will also be handed out during the course. The course will be given at the Solna campus.
Additional course leader Lena Ström
Latest course evaluation Not available
Course responsible Nina Gustafsson
Institutionen för onkologi-patologi

Nina.Gustafsson@ki.se
Contact person -