Course catalogue doctoral education - VT21

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Title Cancer Cell Metabolism
Course number 3076
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2021-05-24 -- 2021-05-28
Responsible KI department Institutionen för mikrobiologi, tumör- och cellbiologi
Specific entry requirements Basic knowledge in Tumor Cell Biology
Purpose of the course The course provides an introduction to cancer cell metabolism. Focus is on the roles of oncogenic signaling and tumor microenvironment as drivers of tumor development and progression. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed.
Intended learning outcomes After the course, the student should be able to:
- describe and explain the role of altered cellular metabolism in cancer development and cancer progression;
- reflect upon the interaction between oncogenic signaling and tumor metabolism;
- discuss how tumor metabolism may be exploited in anticancer therapies and diagnosis/prognosis.
Contents of the course Overview about cell metabolism
The major metabolic pathways
The mitochondrion
Signalling pathways and metabolic control
Cancer cell metabolism
Methods to study cell metabolism
Targeting metabolism for cancer treatment
Teaching and learning activities The course consists of lectures with invited national and international scientists with focus on Cancer cell Metabolism. The students will actively talk to the scientists in the ""Meet the Scientists"" format and discuss the topics during beehive discussions. The course is given full-time during 1 week. The teaching is mainly in lecture/seminar form and also includes project work. This project is presented orally on the last day of the course. The project work requires studies of a specific topic in Cancer Cell Metabolism.

Compulsory elements Attendance at lectures is strongly advised. Participation in the beehive and ""Meet the scientists"" session is mandatory. To compensate for absence due to e.g. illness the student may be required to write a report and/or discuss the missed subject with the course leaders.
Examination Examination is divided into two parts: Firstly, during active participation in the ""Meet the scientists"" seminar and in connection with the beehive group discussion. Secondly, the students will be given an assignment to be presented on the last day of the course. This assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an overview of the field which motivates a specific research question identified by the student/s and a brief work plan that explains how the question/hypothesis can be solved/investigated.
Literature and other teaching material Literature suggestions will be made by the lecturers during the course. In addition, this is a list of suggested literature Cairns RA, Harris IS, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011 Schulze A and Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012 Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012 Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov 2013 Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 2013
Number of students 10 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course will take place in the Biomedicum building, in Campus Solna, with lectures in the mornings and other practical activities in the afternoon. All the teaching will be in English. The course contents will include, but will not be limited to, general introduction to cancer cell metabolism, metabolic tracing, metabolomics and other techniques to study metabolism, cancer cells in a broader physiological context, tumor acidosis, mitochondria and its interactions with other organelles, hypoxia, etc. We will have lecturers from in and outside KI, including an international invited speaker.
Additional course leader Marie Arsenian Henriksson, María Victoria Ruiz Pérez
Latest course evaluation Course evaluation report
Course responsible Marie Arsenian-Henriksson
Institutionen för mikrobiologi, tumör- och cellbiologi

Marie.Arsenian.Henriksson@ki.se
Contact person María Ruiz Pérez
Institutionen för mikrobiologi, tumör- och cellbiologi

maria.ruiz.perez@ki.se