Course catalogue doctoral education - VT24
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| Title | An Introduction to Genetic and Molecular Epidemiology |
|---|---|
| Course number | 3077 |
| Programme | Epidemiologi |
| Language | English |
| Credits | 1.5 |
| Date | 2020-10-19 -- 2020-10-23 | Responsible KI department | Institutionen för medicinsk epidemiologi och biostatistik |
| Specific entry requirements | Knowledge in epidemiology equivalent to the course Epidemiology I: Introduction to Epidemiology or corresponding courses |
| Purpose of the course | The course focuses on basic concepts, methods and study design in genetic and molecular epidemiology research. |
| Intended learning outcomes | After successfully completing this course you are expected to be able to:
- Explain the basic organization of the human genome and the central dogma of eukaryote genetics. - Describe the concepts of meiosis, recombination, linkage and linkage disequilibrium. - Give examples of familial inheritance, discuss how twins can be used in genetic studies, and summarize the last decade´s breakthrough of genome-wide association analyses in complex diseases. - Explain the different types of molecular omics techniques (epigenomics, proteomics, transcriptomics and metabolomics etc.) and how these methods could be used in epidemiological studies. - Describe the fundamentals of study design, sample randomization, and common biases in analyses of genetic and molecular epidemiological data to draw conclusions on how new sample collections should be conducted. Intended learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation (Bloom, 1956, extended by Anderson and Krathwohl, 2001). |
| Contents of the course | The course is about concepts and methods used in studies of genetic variation influencing disease and other
phenotypes. It will cover basic genetic inheritance and how it influences complex and quantitative traits, but will also cover common molecular methods applied in large-scale settings in epidemiology (epigenetics, transcriptomics, metabolomics, etc.). |
| Teaching and learning activities | Flipped classroom approach (blended learning approach) with reading sessions, group discussions with invited experts, lectures, and lab visits. |
| Compulsory elements | The individual examination (summative assessment) is compulsory. |
| Examination | The student has to show that all the intended learning outcomes have been achieved. An individual assessment of the learning outcomes will be a written home essay. Students who do not obtain a passing grade in the first examination will be offered a second chance of submission of home examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered.
|
| Literature and other teaching material | Recommended reading:
Scientific articles and handouts distributed before and during the course. |
| Number of students | 8 - 25 |
| Selection of students | Eligible doctoral students will be prioritized according to 1) the relevance of the course syllabus for the applicant’s doctoral project (according to written information), 2) date for registration as a doctoral student (priority given to earlier registration date). To be considered, submit a completed application form. Give all information requested, including a short description of current research training and motivation for attending, as well as an account of previous courses taken. |
| More information | |
| Additional course leader | Additional course leader is Bruna Gigante, Department of Cardiology, Danderyds Hospital and Department of Medicine Solna, KI. Senior physician and senior lecturer in epidemiology with focus on cardiovascular medicine. |
| Latest course evaluation | Course evaluation report |
| Course responsible |
Sara Hägg Institutionen för medicinsk epidemiologi och biostatistik Sara.Hagg@ki.se |
| Contact person |
Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08-524 822 93 gunilla.nilsson.roos@ki.se |
