Course catalogue doctoral education - VT24
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| Title | The DNA Damage Response in Cancer |
|---|---|
| Course number | 5226 |
| Programme | Tumörbiologi och onkologi (FoTO) |
| Language | English |
| Credits | 1.5 |
| Date | 2020-11-23 -- 2020-11-27 | Responsible KI department | Institutionen för onkologi-patologi |
| Specific entry requirements | |
| Purpose of the course | The course aims to provide the participants with a comprehensive overview about the DNA damage response and its role in cancer development, progression and anti-cancer treatment both with regards to DNA damaging chemo- and radiotherapy as well as emerging treatments targeting key players in the DNA damage response (targeted therapies). |
| Intended learning outcomes | After passing the course, students will
- have gained a comprehensive overview of the DNA damage response - discuss and explain the main mechanistic aspects in different DNA repair pathways and how this and can be exploited in anti-cancer treatment - understand the mechanism of action of DNA damaging inducing anti-cancer treatments and drugs targeting the DNA damage response - describe and understand state-of-the-art strategies for targeting the DNA damage response in cancer - have gained knowledge about different molecular biology assays to study DNA repair and replication in cells and how this can be applied in their own research - understand and theorize about how the DNA damage response connects to different cellular responses such as cell cycle progression and apoptosis and apply this knowledge in their own research projects |
| Contents of the course | The course will cover the following topics:
-Overview of the DNA damage response -The DNA damage checkpoints across the cell cycle -DNA damaging anti-cancer treatment such as chemotherapeutics and radiotherapy -State-of-the-art strategies for targeting the DNA damage response in cancer -DNA damage tolerance -Double-strand break repair -DNA replication stress, fork stalling and interstrand crosslink repair -DNA damage response and human disease -Defective DNA damage responses and cancer -Assays studying DNA repair and replication |
| Teaching and learning activities | The course consists of lectures and seminary by experts in their fields and group exercises. To promote active learning, lectures and seminars are followed by discussions between the students and the speakers and the students will apply knowledge from the course in their own research projects in the examination. |
| Compulsory elements | Attending the lectures, seminars group exercises and the examination seminar are compulsory. Absence can be compensated by other activities after discussion with the course leader. |
| Examination | To pass the course the students must show that they have reached the learning outcomes of the course. The course assignment will consist of:
1) an individual oral presentation about integrating topics from the course in the students’ own research projects in line with the intended learning outcomes of the course. 2) the students are expected to ask questions on each others presentations and be able to discuss and answer questions from fellow students and course leader in line with the intended learning outcomes of the course. |
| Literature and other teaching material | The students will be provided in advance with relevant literature (review articles, original publications).Teaching material will also be handed out during the course.
|
| Number of students | 8 - 25 |
| Selection of students | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date) |
| More information | The course will be held at Karolinska Institutet Solna and Scilifelab Solna. The information regarding exact time will be sent to course participants along with the course schedule. |
| Additional course leader | |
| Latest course evaluation | Not available |
| Course responsible |
Nina Gustafsson Institutionen för onkologi-patologi Nina.Gustafsson@ki.se |
| Contact person | - |
