Course catalogue doctoral education - VT21

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Title Immunometabolism: Implications for Health and Disease
Course number 5214
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Date 2020-11-30 -- 2020-12-04
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements Basic knowledge of immunology (corresponding to the KI doctoral education course Basic Immunology (3 hp) molecular biology, biochemistry and cardiovascular physiology is required.
Purpose of the course This course is intended to provide doctoral students in-depth knowledge on the new scientific advances about the interplay between immunological and metabolic processes, and provide an extra dimension to our understanding of the immune system in health and disease.
Intended learning outcomes After successful completion of this course students are expected to be able to:
- understand the concept of immunometabolism.
- demonstrate detailed understanding of the molecular mechanisms underlying energy metabolism in immune cells and their contribution to the development of metabolic and inflammatory diseases.
- discuss mechanisms that modulate metabolism and can control the immune response.
Contents of the course Our understanding of molecular pathways that govern metabolism and immunology has evolved largely in parallel. However, current evidence points to a close interplay between immunological and metabolic processes. It is now clear that the behavior of cells of our immune system including monocytes, macrophages and lymphocytes is largely determined by the status of their intracellular energy metabolism.

This course will provide an in-depth knowledge about immunometabolism. The course will specifically focus on the molecular mechanisms governed by metabolism that underlie immune cell functioning including oxidative phosphorylation and glycolysis.
Furthermore, the concept of immunometabolism will be applied to various pathological conditions ranging from host defense against infections, cancer and cardiometabolic diseases and related complications. Of note, during the course it will be discussed how targeting of metabolism in immune cells can lead to tangible therapeutic advancements to promote health.
Teaching and learning activities Lectures, project group work, presentation by participants
Compulsory elements Examination is compulsory to pass the course.
Examination To pass the course, the participant has to:
1) Give a satisfactory presentation in a seminar and to be able to discuss the different aspects of immunometabolism with the course leader and the other participants.
2) To be able to discuss the other participants' presentations.
3) Pass a written exam recapitulating the course's content.
Literature and other teaching material Recommended reading:
1. O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. A guide to immunometabolism for immunologists. Nature Reviews Immunology (2016).
2. Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., et al. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research (2019).
3. Pearce, E. L., & Pearce, E. J. Metabolic pathways in immune cell activation and quiescence. Immunity (2013).
4. Mathis, D., & Shoelson, S. E. Immunometabolism: an emerging frontier. Nature Reviews Immunology (2011).
Number of students 8 - 30
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information
Additional course leader Daniel Ketelhuth
Latest course evaluation Not available
Course responsible Maria Forteza de los Reyes
Institutionen för medicin, Solna
0704608018
maria.forteza.de.los.reyes@ki.se

Akademiska stråket, 1

17164
Solna
Contact person Daniel Ketelhuth
Institutionen för medicin, Solna

Daniel.Ketelhuth@ki.se


Maria Forteza de los Reyes
Institutionen för medicin, Solna
0704608018
maria.forteza.de.los.reyes@ki.se

Akademiska stråket, 1

17164
Solna