Course catalogue doctoral education - VT21

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Title Cancer Genetics: a Basis for Precision Medicine
Course number 5230
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2020-11-16 -- 2020-11-20
Responsible KI department Institutionen för molekylär medicin och kirurgi
Specific entry requirements
Purpose of the course Thanks to the introduction of next-generation sequencing technologies, the genomic landscape of many cancer types, including both solid tumors and haematological malignancies, have been rapidly unraveled. This has provided essential information about recurrent genetic events and identified key pathways and processes deregulated in each cancer type. Based on this knowledge, an array of genetic markers have been identified with diagnostic, prognostic and predictive impact, that also has paved the way for the development of new targeted therapies. Today, cancer genetics provides an important basis for precision cancer diagnostics, which in turn enables individually adapted therapies and follow-up strategies. The purpose of this course is to bring the students to an advanced level in the rapidly developing field of cancer genetics and precision medicine, and to provide knowledge that can be applied for basic, translational as well as clinical research.
Intended learning outcomes After the course, the participants should have knowledge on the biological and clinical impact of cancer genetics as a basis for precision diagnostics/medicine in solid tumors and haematological malignancies. They should be able to select adequate genomic technologies and data analysis strategies for cancer research projects and clinical diagnostics. They should be able to evaluate different categories of gene mutations using publicly available databases and tools. Finally, they should be able to identify and discuss ethical issues arising from large-scale next-generation sequencing studies.
Contents of the course The latest research in cancer genetics including i) currently available technologies and technology development, ii) the impact of cancer genomics in solid tumors and haematological malignancies and iii) the strong potential of precision diagnostics as one of the two pillars of precision medicine will be presented and discussed. The course is primarily aimed at students actively involved or planning genetic analysis for basic, translational and clinical cancer projects.

Teaching and learning activities The course consists of lectures, seminars, hands-on computer-based exercises, self-studies, and group
presentations.
Compulsory elements The course seminar as well as the examination are compulsory. Absence from compulsory parts is compensated according to the instructions from the course leader.
Examination The course assessment will consist of a written single best answer (SBA) exam, including some open-end questions covering ethical issues, to assess whether each individual doctoral student has reached the learning outcomes of the course.
Literature and other teaching material Reference literature will be recent scientific articles.
Number of students 10 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information
Additional course leader Felix Haglund, felix.haglund@ki.se
Latest course evaluation Not available
Course responsible Richard Rosenquist Brandell
Institutionen för molekylär medicin och kirurgi

richard.rosenquist@ki.se
Contact person -