Course catalogue doctoral education - VT21

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Title Endothelial Cell Function and its Relevance in Cardiovascular Disease
Course number 3113
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Date 2020-11-09 -- 2020-11-13
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements
Purpose of the course This course is specially planned to give the participants in the area of cardiovascular research a global perspective on endothelium pathophysiology as well as advanced cutting-edge approaches used by researchers.
This course will enable the participants to obtain the required knowledge to understand and study endothelial cell function in cardiovascular disease.
Intended learning outcomes Upon completion of the course, the students should be able to:
1. show an in depth knowledge of endothelial cell function and related molecular basis;
2. evaluate endothelial cell dysfunction and its relevance to cardiovascular disease (e.g. atherosclerotic lesion, diabetes, ischemia and infection);
3. show an insight into the application of state of the art models and technologies (in vitro, in vivo, from animal model to clinic study) for studying endothelial cell function in cardiovascular disease.
Contents of the course Endothelial cells and endothelial cell function under various physiological and pathological conditions will be discussed from molecular, cellular, organ and clinical perspectives. Topics to be covered include the roles of endothelial cells in atherosclerosis, ischemic heart disease, inflammation, hypertension and diabetes/insulin resistance, and in mechanisms of current and future treatment. The course will include examples of in vitro and animal models for evaluation of endothelial cell function as well as examples of clinical studies.
Teaching and learning activities The course activities include daily interactive lectures and seminars given by invited scholars in the respective fields, lab demonstrations, group learning (literature review and research planning), and a group project presentation and review on the last day of the course.
Compulsory elements Students need to participate in all learning activities and to complete self learning assignments. Absence maybe compensated for by an extra task in agreement with the course organizer. The final examination must be passed in order to pass the course.
Examination The final assessment will be held in two parts:
1) a literature review and discussion in groups;
2) an oral presentation of a research project in the field of endothelial cell function, which should be designed at least partially using the knowledge from the course lectures and experimental methods from the lab demonstration.
In order to pass the course, each student needs to show that he or she reached all the learning outcomes of the course.

Literature and other teaching material Recommended literature:
The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.
Böhm F, Pernow J. Cardiovasc Res. 2007 Oct 1;76(1):8-18. Review.
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Pernow J, Jung C. Cardiovasc Res. 2013 Jun 1;98(3):334-43. Review.
Therapeutic targets for endothelial dysfunction in vascular diseases. Huynh DTN, Heo KS. Arch Pharm Res. 2019 Oct;42(10):848-86. Review
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date).
More information Location: Bioclinicum KI Hospital Solna Time: 09.00-17.00 all days
Additional course leader Xiaowei Zheng, email: Xiaowei.Zheng@ki.se, Department of Molecular medicine and surgery. Rosa Suades Soler, email: rosa.suades.soler@ki.se, Department of Medicine Solna.
Latest course evaluation Course evaluation report
Course responsible Jiangning Yang
Institutionen för medicin, Solna

Jiangning.Yang@ki.se
Contact person Jiangning Yang
Institutionen för medicin, Solna

Jiangning.Yang@ki.se


Rosa Suades Soler
Institutionen för medicin, Solna

rosa.suades.soler@ki.se


Xiao-Wei Zheng
Institutionen för molekylär medicin och kirurgi

xiaowei.zheng@ki.se