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| Title | Basic Immunology |
|---|---|
| Course number | 5229 |
| Programme | Allergi, immunologi och inflammation (Aii) |
| Language | English |
| Credits | 3.0 |
| Date | 2020-09-07 -- 2020-09-30 | Responsible KI department | Institutionen för medicin, Solna |
| Specific entry requirements | Knowledge in basic cell biology. |
| Purpose of the course | To give doctoral students the possibility to acquire a solid knowledge and understanding of fundamental principles in immunology.
All other courses in the doctoral education program Aii (Allergy, immunology and inflammation) assume that students have taken the Basic Immunology course, or otherwise have previously attained the same level of knowledge and understanding. |
| Intended learning outcomes | To be able to:
- Explain the basic principles of innate and adaptive immunity and how different components of the immune system cooperate - Describe and compare experimental aspects of immune-related diseases in a clinical perspective. - Apply knowledge gained on the function of the immune system to write a research project proposal in immunology that will be discussed in pairs - Review a chosen immunological/clinical topic, which will be presented as a group project |
| Contents of the course | The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defense against infection, autoimmune and allergic diseases or transplantation.
Part 1: An overview of the immune system, T cells, B cells, Antigen presenting cells, Innate lymphoid cells, Innate vs adaptive immune responses. Part 2: Immune defense against bacterial and viral infections, Primary immunodeficiencies, Autoimmune disease, Allergy, Vaccination, Clinical Immunology, Transplantation, Tumor Immunology. Questions and discussions. Presentation of projects. |
| Teaching and learning activities | Lectures and seminars are given three days per week and remaining days are assigned for project work, a written assignment as well as reading. The project work and written assignment require studies between the two course parts, including meetings with mentors. On the last day of the course, the project work will be presented orally. An immunological quiz is connected to the different topics of the course, so that the student will be able to digest the relatively big material. The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts.
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| Compulsory elements | All activities included in the course are compulsory. Absence needs to be compensated for in agreement with the course director.
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| Examination | The student will be examined on both the project work and the written assignment. The project work will be evaluated by the group project mentor and by the course organisers during the oral presentations of the work. At this occasion special attention is given to all student´s active participation and contributions to the discussions. The individual written assignment is evaluated by the course organisers.
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| Literature and other teaching material | Mandatory literature: Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai: Basic Immunology: Functions and Disorders of the Immune System. 6th edition. (Elsevier – Health Sciences Edition).
Lecture handouts uploaded to the course website. Scientific review articles proposed by group project mentors. |
| Number of students | 10 - 25 |
| Selection of students | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). |
| More information | The course is divided into two sessions with 3 days of lectures each, September 7th to 9th (Monday to Wednesday) and September 28th to 30th (Monday to Wednesday). In between these days of lectures, the students work on both a group project and an individual written assignment, including meetings with mentors and literature studies. The first meeting with mentors should ideally take place on either the 10th or 11th of September (Thursday or Friday, respectively), so students are expected to have time to devote to the course outside the official lecture days. Teachers include specialists in different fields of immunology including both basic and clinical researchers. The course location is at the Center for Molecular Medicine (CMM), Karolinska University Hospital, Solna. The course has previously been given with number 3187 (see linked course evaluation). |
| Additional course leader | nicolas.ruffin@curie.fr, Andre.Ortlieb@ki.se |
| Latest course evaluation | Course evaluation report |
| Course responsible |
Karine Chemin Institutionen för medicin, Solna karine.chemin@ki.se |
| Contact person | - |
