Course catalogue doctoral education - HT20

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Title Regenerative Medicine: Principles to Practice
Course number 3060
Programme Utveckling och regeneration (DevReg)
Language English
Credits 3.0
Date 2019-09-25 -- 2019-12-11
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements None.
Purpose of the course The overall purpose of the course is to expose students to the latest scientific findings in the field of regenerative medicine, and to provide students with skills to conceptually develop independent lines of research within collaborative international networks.
Intended learning outcomes After completion of this course, the student will be able to describe the basics of stem cell biology and provide an appreciation for novel approaches and applications in regenerative medicine. The student will be able to demonstrate an interdisciplinary understanding of central concepts in stem cells and critically evaluate the potential, advantages and drawbacks of different methods that are currently researched in the fields of stem cell and regenerative therapy. The student will be able to extract and integrate information from state-of-the-art lectures, scientific articles and literature search within the field.
Contents of the course The course covers principles of stem cell biology and provides an appreciation for applications in regenerative medicine. Lectures and journal club-based topics include fundamental features of stem cell platforms, as well as the use of these and other platforms in the design and development of regenerative therapies. The course will exemplify how regenerative therapies can be targeted to different organs (e.g. within the cardiovascular system and the nervous system) with particular emphasis on the state-of-the-art technologies, prospects for clinical translation and current challenges within the field. The student will be required to take an active part in this course by contributing in journal clubs and discussions related to stem cell-based regenerative medicine.
Teaching and learning activities The pedagogic frame of this course is based on lectures combined with topic-related research articles. Approximately half of the lectures will take place at KI (Flemingsberg and Solna campus). The other lectures will take place at Mayo Clinic and will be projected to students at KI via video conferencing. The course includes journal clubs where the students are required to present articles (written and orally), integrate the knowledge acquired from lectures and reading of the articles, and actively discuss their acquired knowledge as a group. Some journal clubs will be carried out in groups using interactive e-platforms. The examination task consists of a written report that is handed in for evaluation toward or at the completion of the course.
Compulsory elements Active participation in lectures and journal club-based discussions is mandatory. Compensation according to the instructions of the course director.
Examination The examination consists of a written report that is handed in for evaluation at the end of the course. All students are also required to peer-review another student's examination report. The individual performance of each student will be evaluated separately.
Literature and other teaching material The course literature will consist of recent original and review papers on selected topics within the field of regenerative therapy.

Examples of articles:
1. Rivetti di Val Cervo P et al (2017). Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Nat. Biotechnology.

2. Carrelha et al (2018). Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells. Nature.

3. Passier R et al (2008) Stem-cell-based therapy and lessons from the heart. Nature.

4. Chiappini C et al (2015) Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nature Materials
Number of students 8 - 12
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information Lectures are held Wednesdays 15:00-17:00. Speakers will give their lectures at either the Mayo clinic (USA) or the Karolinska Institutet (SWE), and will be projected to students at the other site via video conferencing.
Additional course leader
Latest course evaluation Course evaluation report
Course responsible Martin Enge
Institutionen för onkologi-patologi
Contact person Martin Enge
Institutionen för onkologi-patologi