Course catalogue doctoral education - HT20

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Title Neurodegenerative disorders I - From molecule to treatment
Course number 2629
Programme Neurovetenskap
Language English
Credits 1.5
Date 2019-09-30 -- 2019-10-04
Responsible KI department Institutionen för neurobiologi, vårdvetenskap och samhälle
Specific entry requirements
Purpose of the course The purpose of the course is to introduce clinical aspects and molecular mechanisms in the most common neurodegenerative disorders and to use this knowledge to prepare and present oral presentations as well as ask and answer questions. The course will also allow interaction between PhD-students with master students in their second year, both with a special interest in neuroscience. A potential purpose for students attending all 6 courses given in sequence (Frontiers Courses in Neuroscience) is also to place Neurodegenerative disorders in a greater research context.
Intended learning outcomes The student should after the course: 1) understand cellular processes and molecular mechanisms of neurodegeneration 2) understand mechanisms of protein turnover, degradation and aggregation 3) based on knowledge of these mechanisms critically be able to evaluate the concept of conformational disorders and its relevance to the different neurodegenerative disorders 4) have achieved basic knowledge about epidemiology, symptoms, pathology and current treatments of the most common neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis and multiple sclerosis. 5) In addition, the student should understand how the pathology of these disorders is reflected in their symptoms. 6) Based on this understanding, the student should be able to discuss the effects of treatments, if they are (or may be) symptomatic or curative. 7) Be able to evaluate the relevance of different disease models, their advantages and limitations with respect to the clinical picture and to what is known about disease mechanisms.
Contents of the course The course will cover topics related to the degeneration of neural cells, apoptosis and necrosis as well as the cellular and biochemical reactions to neuronal injury. During the course we will also present and discuss symptoms, diagnosis, pathology, epidemiology, genetics and treatment of the most common neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis and multiple sclerosis. Molecular mechanisms of current and future treatment strategies, disease models and their potential will be presented and discussed. In addition, the students may within group assignments study less common neurodegenerative diseases such as frontotemporal dementia, Lewy body disease, ataxias, prion diseases as well as vascular, inflammatory or trauma related causes of neurodegeneration such as stroke, epilepsy or trauma.
Teaching and learning activities The course runs day time for 1 week full-time with lectures by invited scientists, literature seminars as group assignments, and individual studies.
Compulsory elements The group assignments, the oral presentations by the students and the following general discussion between all participants are compulsory. Students that are absent from these parts will have to individually submit a written presentation of the subject.
Examination The examination part includes: the group assignments, short formative examination questions at the end of day during the course week, the oral presentations by the students and the following general discussion between all participants. All students are individually assessed.
Literature and other teaching material 1. Principles of neural science, Kandel et al., 5th ed, 2013
(In particular chapter 44, Pp 999-1014 and chapter 50, pp 1116-1139)
2. Articles and hand outs from the course organizers and respective lecturer

(3. For those interested: E-books, available at KIB
-Neurodegenerative Disorders: A Clinical Guide, Hardiman, Orla. London : Springer London, 2011.
-Neuropathology of neurodegenerative disorders, Kril, Jillian. London: Henry Stewart Talks, 2007 (E-film, 29 min)
-Mitochondrial Dysfunction in Neurodegenerative Disorders, Reeve, Amy Katherine. Springer London, 2012.
-Intracellular Traffic and Neurodegenerative Disorders, George-Hyslop, Peter H. St. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009
-The role of the ubiquitin-proteasome system in neurodegenerative disorders. Verhoef, Lisette Gerridina Gezina Catharina, Stockholm, 2006)

Number of students 10 - 25
Selection of students If selection of course participants is necessary, we will prioritize 1) students for whom the course is mandatory, 2) students with an educational plan encompassing the topics of the course, and 3) PhD-students with an early registration date and close to finalizing the doctoral studies.
More information The course will be held at Karolinska Institutet, Solna
Additional course leader Helena Karlström, NVS, KI
Latest course evaluation Course evaluation report
Course responsible Elisabet Åkesson
Institutionen för neurobiologi, vårdvetenskap och samhälle
Contact person Maria Roos
Institutionen för neurobiologi, vårdvetenskap och samhälle

Helena Karlström
Institutionen för neurobiologi, vårdvetenskap och samhälle