Course catalogue doctoral education - HT20

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Title Thrombosis and Hemostasis, from mechanisms to therapies
Course number 2484
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Date 2019-11-04 -- 2019-11-08
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements
Purpose of the course The aim of the course is that doctoral students acquire in-depth knowledge of thrombosis and hemostasis, as well as to elucidate the links between molecular mechanisms and clinical disorders and to introduce current advances and future directions of thrombosis research.
Intended learning outcomes The concept from bench to bed side and back will be reinforced at all levels. Therefore, at the end of the course the students should be able to:
1. Describe the molecular and cellular mechanisms of haemostasis and thrombosis, as well as the dynamic processes of primary haemostasis, secondary haemostasis, and thrombosis.
2. Explain the mechanisms underlying bleeding and thrombotic disorders.
3. Have a good understanding of current anticoagulant and antiplatelet therapies, and obtain a clear view of the challenges of future anticoagulant and antiplatelet drug developments.
4. Apply current knowledge of thrombosis and haemostasis into future research design and to formulate new treatment strategies.
5. Sharpen the sense of critical appreciation of research literature, and strengthen their ability to develop new research concepts through critical reading.
Contents of the course The course aims to bring in in-depth knowledge of thrombosis and hemostasis, and to emphasize a translational view, from bench to bed side and back, of the hemostatic system to the students. The course is designed for the students who work in both basic and clinical aspects of hemostasis, thrombosis and cardiovascular research. The following aspects of hemostasis and thrombosis will be discussed: biochemistry of the blood clotting system; cell-cell and cell-protein interactions in the cardiovascular system in relation to thrombosis and bleeding disorders; cross-talks of the clotting system with inflammation, host defense and complement systems; diagnosis of bleeding and thrombotic disorders; therapeutic strategies to fight thrombosis and bleeding with the emphasis placed on new pharmacological concepts.
Teaching and learning activities Lectures
Group work
Presentation of papers related to the key lectures
Compulsory elements To participate in the lectures, group work and presentation of the group work is compulsory. The students who have missed the group work sessions can book extra session time within 4 weeks to compensate the absence. Absence in lectures should be compensated for in accordance with the course director.
Examination Presentation of a paper related to key lectures
Short written homework.
Multiple-choice test.
Literature and other teaching material The course will provide organized handouts from all lectures.
Textbook: Marder VJ, Aird WC, Bennett JS, Schulman S, White GC. Hemostasis and Thrombosis: basic principles and clinical practice. Philadelphia, Lippincott Williams & Wilkins; 6th edition, 2012.
Number of students 8 - 25
Selection of students Selection will be based on: 1) The relevance of course subject to the applicant's research project (according to written motivation) 2) Importance/urgency of thrombosis and coagulation knowledge for the applicant's research project (according to written motivation) 3) Previous application (priority given to those who have applied previously)
More information The course will be held during week 45 (9:00-16:30). Lecture hall booked: Course room 1 (the room by Japanese garden), L2:U1 at Karolinska University Hospital-Solna. The course includes 16 lectures given by the experts in corresponding subjects, group work, as well as group work presentation and discussion. The course has been organized many times at KI during last two decades. The course has been well received by the participants, and is known for its good coverage of course subject and well-balanced pre-clinical and clinical contents.
Additional course leader
Latest course evaluation Course evaluation report
Course responsible Nailin Li
Institutionen för medicin, Solna

Clinical Pharmacology Unit
Karolinska University Hospital-Solna
Contact person Angela Silveira
Institutionen för medicin, Solna