Kurskatalog forskarutbildning - HT21

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Titel Biomedical Ecology - The microbiota in health and disease
Kursnummer 2861
Program X- Används inte längre - Infektionsbiologi
Språk Engelska
Antal högskolepoäng 1.5
Datum 2015-11-23 -- 2015-11-27
Kursansvarig institution Institutionen för mikrobiologi, tumör- och cellbiologi
Särskild behörighet
Kursens lärandemål After finishing the course the student should be able to show knowledge about:
-the composition and function of the intestinal microbiota and its cross talk with the host.
-the establishment of the microbiota during different stages of life, and its impact on the development and function of the immune system and host tissues.
-the role of how an altered intestinal function and dysbiosis might occur in connection with different diseases/disturbances.

The student should be able to show insight in:
- methods to study the intestinal microbiota as well as data analyses and interpretation.
-the microbiota as the largest metabolic organ in the body and its physiological and pathophysiological role in health and disease.
-the role of the host-microflora cross-talk for the intestinal ecology/homeostasis.
Kursens innehåll The course will cover the aspects of the composition and function of the intestinal microbiota from birth, during life and the ageing period, how it might be influenced by diet and disease, and host-microbe crosstalk. Sequencing techniques will be introduced for the study the microflora and compared to biochemical methods. Novel findings will be discussed by lecturers in the research front-line on the translational topics of normal flora in relation to inflammatory bowels diseases (IBD), irritable bowels syndrome (IBS) celiac disease, reumatological and neurophysiological diseases.

The course will be suitable for clinical and pre-clinical PhD students and researchers where the microbiota is of significance, including areas such as allergy, asthma, systemic autoimmune diseases, cardiovascular diseases, obesity, rheumatology, neurophysiological disturbances such as autism spectrum disorders, chronic fatigue, nutrition - including effects of pre- and probiotics, diabetes, metabolic syndrome, infectious diseases and bioinformatics.
The course replaces the previous course 2300.
Arbetsformer The course will combine lectures, student work shops and student seminars, and practical laboratory work
-lectures by well established front-line researchers in their respective fields.
-laboratory experiments on the students own intestinal flora.
-work shops/combined with focused literature studies within defined areas which will be summarized in terms of student seminars.
- flipped class room and peer learning using the competence of the course attendees.
Obligatoriska moment Laboratory work and student workshops and seminars. Participants that are absent from the laboratory part and seminars will have to present a written paper on the subject.
Examination Summative examination includes laboratory work and student presentations that are evaluated by the respective tutor at the specific course module and written examination of the course content by multiple-choice questions covering all topics discussed.
Kurslitteratur och övriga läromedel Microbial Inhabitants of Humans¿Their Ecology and Role in Health and Disease by Michael Wilson 2005, which will serve as an introduction and is recommended.
The students will also receive the latest publications and/or review articles from respective lecturer within the areas discussed.
For Swedish students, there is suitable litterature available; Magen: Bakterier, buller och brak by Benno P, Ernberg I, Medtvedt T, Möllby R, Norin E & Svenberg T, 2012
Additional reading; Missing Microbes by Martin Blaser 2014
Links to on line lectures on the topic of microbiota will be provided prior to the course start.
Antal studenter 12 - 24
Urval av studenter Selection will be based on the relevance of the course syllabus for the applicant's doctoral project (according to written motivation).
Övrig information
Ytterligare kursledare
Senaste kursvärdering Not available
Kursansvarig Åsa Sjöling
Institutionen för mikrobiologi, tumör- och cellbiologi
08-524 875 04
asa.sjoling@ki.se
Kontaktpersoner Katrin Pütsep
Institutionen för mikrobiologi, tumör- och cellbiologi

Katrin.Putsep@ki.se