Course catalogue doctoral education - HT21

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Title Biomedical Ecology - The microbiota in health and disease
Course number 2861
Programme X- No longer used - Infection Biology
Language English
Credits 1.5
Date 2015-11-23 -- 2015-11-27
Responsible KI department Department of Microbiology, Tumor and Cell Biology
Specific entry requirements
Intended learning outcomes After finishing the course the student should be able to show knowledge about:
-the composition and function of the intestinal microbiota and its cross talk with the host.
-the establishment of the microbiota during different stages of life, and its impact on the development and function of the immune system and host tissues.
-the role of how an altered intestinal function and dysbiosis might occur in connection with different diseases/disturbances.

The student should be able to show insight in:
- methods to study the intestinal microbiota as well as data analyses and interpretation.
-the microbiota as the largest metabolic organ in the body and its physiological and pathophysiological role in health and disease.
-the role of the host-microflora cross-talk for the intestinal ecology/homeostasis.
Contents of the course The course will cover the aspects of the composition and function of the intestinal microbiota from birth, during life and the ageing period, how it might be influenced by diet and disease, and host-microbe crosstalk. Sequencing techniques will be introduced for the study the microflora and compared to biochemical methods. Novel findings will be discussed by lecturers in the research front-line on the translational topics of normal flora in relation to inflammatory bowels diseases (IBD), irritable bowels syndrome (IBS) celiac disease, reumatological and neurophysiological diseases.

The course will be suitable for clinical and pre-clinical PhD students and researchers where the microbiota is of significance, including areas such as allergy, asthma, systemic autoimmune diseases, cardiovascular diseases, obesity, rheumatology, neurophysiological disturbances such as autism spectrum disorders, chronic fatigue, nutrition - including effects of pre- and probiotics, diabetes, metabolic syndrome, infectious diseases and bioinformatics.
The course replaces the previous course 2300.
Teaching and learning activities The course will combine lectures, student work shops and student seminars, and practical laboratory work
-lectures by well established front-line researchers in their respective fields.
-laboratory experiments on the students own intestinal flora.
-work shops/combined with focused literature studies within defined areas which will be summarized in terms of student seminars.
- flipped class room and peer learning using the competence of the course attendees.
Compulsory elements Laboratory work and student workshops and seminars. Participants that are absent from the laboratory part and seminars will have to present a written paper on the subject.
Examination Summative examination includes laboratory work and student presentations that are evaluated by the respective tutor at the specific course module and written examination of the course content by multiple-choice questions covering all topics discussed.
Literature and other teaching material Microbial Inhabitants of Humans¿Their Ecology and Role in Health and Disease by Michael Wilson 2005, which will serve as an introduction and is recommended.
The students will also receive the latest publications and/or review articles from respective lecturer within the areas discussed.
For Swedish students, there is suitable litterature available; Magen: Bakterier, buller och brak by Benno P, Ernberg I, Medtvedt T, Möllby R, Norin E & Svenberg T, 2012
Additional reading; Missing Microbes by Martin Blaser 2014
Links to on line lectures on the topic of microbiota will be provided prior to the course start.
Number of students 12 - 24
Selection of students Selection will be based on the relevance of the course syllabus for the applicant's doctoral project (according to written motivation).
More information
Additional course leader
Latest course evaluation Not available
Course responsible Åsa Sjöling
Department of Microbiology, Tumor and Cell Biology
08-524 875 04
asa.sjoling@ki.se
Contact person Katrin Pütsep
Institutionen för mikrobiologi, tumör- och cellbiologi

Katrin.Putsep@ki.se