Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
Swedish title | Antigen presentation och T-cellsaktivering |
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English title | Antigen Presentation and T cell Activation |
Course number | 5739 |
Credits | 1.5 |
Responsible KI department | Department for Clinical Science, Intervention and Technology |
Specific entry requirements | Basic immunology course, or otherwise have attained the same level of previous knowledge. |
Grading | Passed /Not passed |
Established by | The Committee for Doctoral Education |
Established | 2023-09-20 |
Purpose of the course | This course will provide an overview of antigen presentation and T cell activation.
This course is suitable for PhD students with basic immunology knowledge who want to deepen their knowledge in important aspects of various lymphocyte subsets biology. |
Intended learning outcomes | - Describe and compare different types of antigen capture and processing, antigen presentation pathways, e.g. MHC class I & II, MR1 and CD1 system, peptide/lipid/glycolipid presentation, as well as the main T cell subsets and invariant lymphocytes.
- Identify gaps of knowledge about T lymphocyte activation, differentiation, and antigen-presentation. - Formulate a research question (including experimental plan) related to lymphocyte activation in steady state, disease, or cell therapy. |
Contents of the course | The following will be covered during the course:
Thorough walk-through of the antigen presentation pathways, both MHC class I and II, upstream and downstream of TCR activation. The CD1 system, presentation of lipids, glycolipids, MR1 presentation and MAIT cell activation will be discussed. Manipulation of T cell activation for instance by checkpoint inhibitors, T cell exhaustion, the impact of tumor micro-environment, and practical applications such as immunotherapy, will also be covered. |
Teaching and learning activities | The course will be based on lectures, as well as time for questions and discussions.
In addition, work (in small groups) will enable the students to gain deeper knowledge in a specific area of interest. The students are also given literature (see below) in order to prepare for the lectures and discussions. |
Compulsory elements | All lectures and group sessions are considered mandatory.
Missed events should be compensated for with a written report on the subject in accordance with the indications of the course organizer. |
Examination | To pass the course, the student has to show that the learning outcomes have been reached.
The students will be assessed with a group project in an oral presentations. The focus of the examination is gain of knowledge rather than test of knowledge |
Literature and other teaching material | Recommended review articles and selected articles relevant to the lectures (invited speakers will also be asked to suggest papers), will be distributed during or prior to the course.
Examples: - T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol. 2015;33:169-200. Rossjohn et al. - The burgeoning family of unconventional T cells. Nat Immunol. 2015; 16(11):1114-23.Godfrey DI et al. - Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61.Malissen B. -Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies. Cancer Cell. 2017;31(3):311-325. Anderson KG et al. |
Course responsible |
Isabelle Magalhaes Department for Clinical Science, Intervention and Technology 0739752974 Isabelle.Magalhaes@ki.se |
Contact person |