Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Strålningsbiologi |
|---|---|
| English title | Radiobiology |
| Course number | 2516 |
| Credits | 3.0 |
| Responsible KI department | Institutionen för onkologi-patologi |
| Specific entry requirements | |
| Grading | Passed /Not passed |
| Established by | The Board of Doctoral Education |
| Established | 2011-03-23 |
| Purpose of the course | |
| Intended learning outcomes | After successfully completing this course it is expected that the student will be able to: account for how the fundamental mechanisms for the biological effects of radiation both on cells and on organs and organisms as a basis for further studies in applied radiation physics account for the response to radiation is modified by different factors be able to apply the knowledge on research questions in radiation therapy, diagnostic radiology and radiation protection |
| Contents of the course | The course is structured on four major sections covering the clinical and the molecular aspects of radiobiology. I. Introductory lectures, including a description of the physics of radiation interaction and microdosimetrical aspects II. Molecular radiobiology, including the description of the molecular basis of radiation response (genetic pathways, DNA response, apoptosis and checkpoints) and the molecular approaches to radiation therapy III. Basic radiobiology, focusing on the clonogenic cells, cell death and survival, repair of radiation damage and dose-rate effect, models of radiation cell killing, LET and RBE and biological dosimetry and management of radiation accidents IV. Clinical radiobiology, including various aspects such as radiation biology in the clinic from the point of view of the medical doctor, time and dose in radiation therapy, oxygen effect and tumour hypoxia, treatment strategies to overcome tumour radioresistance, radiosensitizers and bioreductive drugs, clinical response of normal tissue, dose-response relationships from clinical data, radiation induced damage in long term survivors The lectures covering these topics are addressing both the fundamental aspects and the state-of-the-art findings in radiobiology which make the subject of the current research directions in the field of molecular and clinical radiobiology applied in radiation therapy and radiation protection. |
| Teaching and learning activities | Lectures and calculation exercises |
| Compulsory elements | Only the examination is compulsory. |
| Examination | |
| Literature and other teaching material | Recommended textbook: Hall E J and Giaccia A J: Radiobiology for the Radiologist Lippincott Williams and Wilkins 2006. | Course responsible |
Iuliana.Livia Dasu Institutionen för onkologi-patologi Iuliana.Livia.Dasu@ki.se |
| Contact person |
