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Svensk benämning	Epigenetik i klinisk medicin
Engelsk benämning	Epigenetics in Clinical Medicine
Kursnummer	2478
Antal högskolepoäng	1.5
Kursansvarig institution	Institutionen för klinisk neurovetenskap
Särskild behörighet
Betygsskala	Godkänd/Icke godkänd
Fastställd av	The Board of Doctoral Education
Datum för fastställande	2010-09-28
Kursens syfte
Kursens lärandemål	After the course the student should be able to discuss how genetic predisposition to epigenetic changes makes the basis for individual vulnerability to disease, describe basic and advanced epigenetic principles and theory of current methods and be oriented on basic bioinformatic tools to help in integrating genetic and epigenetic data.
Kursens innehåll	The course will give the student a basis to understand factors that regulate phenotypes in disease from an epigenetic perspective. Phenotypic plasticity will be explained as a molecular dynamics on gene/environment interaction using epigenetic tools. The course will start with one day introductory lectures on basic theoretical epigenetic principles. This will be followed by three full days of lectures by the leading scientists in the field ""Epigenetics in Clinical Medicine"". Interactive exercises will be organized during these days. The last day will be focused on epigenetic methodologies and bioinformatics.
Arbetsformer	Predominantly cathedral lectures by international top scientists, followed by interactive discussions with these. Each of the three lecture days, will be ended by a one hour discussion in group, where the students will lead the discussion of the subjects presented during the day, in presence of the course organizers.
Obligatoriska moment	All parts are mandatory. Absence from a lecture or discussion may be compensated by a written assignment, on agreement with the course leader.
Examination	Both written and oral form. Written test covering the 5 days' content will be complemented by assessment of the group discussions. Focus will be on understanding of epigenetic mechanisms in disease.
Kurslitteratur och övriga läromedel	One full special issue on ""Epigenetic control of Gene Expression"", Biochim. Biophys. Acta, Vol. 1790, Issue 9, Sept. 2009, pp. 845 - 947.
Kursansvarig	Tomas Ekstrom Institutionen för klinisk neurovetenskap 08 517746 34 073 982 3611 Tomas.Ekstrom@ki.se Karolinska sjukhuset, L8:01 17176 Stockholm
Kontaktpersoner	Ingemar Ernberg Institutionen för mikrobiologi, tumör- och cellbiologi +46852486262 Ingemar.Ernberg@ki.se Box 280, Karolinska Institutet 17177 Stockholm Tomas Ekstrom Institutionen för klinisk neurovetenskap 08 517746 34 073 982 3611 Tomas.Ekstrom@ki.se Karolinska sjukhuset, L8:01 17176 Stockholm

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