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Swedish title Molekylär Endokrinologi- en översikt
English title Survey of Molecular Endocrinology
Course number 2381
Credits 3.0
Responsible KI department Institutionen för medicin, Huddinge
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2009-10-14
Purpose of the course
Intended learning outcomes After successfully completing this course, student should have obtained a fundamental knowledge of molecular endocrinology and acquired the following abilities:
1. explain the molecular mechanisms by which peptide and steroid hormones activate their receptors to provoke their biological effects
2. comprehend how the actions of hormones are involved in diseases
3. construct pathways of the endocrine systems that link control and production of hormones in specific tissues with the actions of these hormones in their respective target organs
4. analyse and evaluate scientific reports within the research field of molecular endocrinology
5. develop an in-depth comprehensive knowledge of endocrinology from a physiological, cellular, and molecular perspective
6. incorporate knowledge learned from this course to critically evaluated clinical and research case problems relating to molecular endocrinology mechanisms
7. evaluate clinical, translational and basic research articles critically and conceptualize alternative interpretations approaches and theories from primary molecular endocrine principles learned in the course
8. structure principles endocrine concept proposal in hypothesis driven objectives for a research grant
9. prepare for public speaking infront of a scientific audience
Contents of the course -This course will cover current topics involved in hormone signalling at a cellular and molecular level from receptor interaction to gene response including receptor structure and function interactions with their hormone, second messengers, transcription regulation and autocrine and paracrine feedback signalling pathways.

-The course will emphasize the critical understanding of how hormones act at the molecular level and why their signalling pathways synergize or antagonize each other under normal and pathological physiological conditions.

-A survey of current topics in endocrinology will be used to exemplify the concepts of the course such as stem cell commitment and differentiation, the molecular signalling and genetics of embryogenesis; reproductive determination and differentiation; cancer stem cell dedifferentiation and carcinogenesis; hormonal regulation of gene expression, steroid and peptide hormone action via paracrine, autocrine signalling; endocrine mechanisms of receptor interaction, transmembrane and intracellular signal transduction, ionic signalling, and regulation of nuclear gene transcription.
Teaching and learning activities The course will consist of cathedral-style lectures to exposure students to fundamental molecular endocrine concepts, current topic seminars to exemplify concepts, and student-led seminars and discussions to allow the students an opportunity to utilize conceptual knowledge within an informal environment.
Compulsory elements The students are expected to attend all lectures and seminars. They are expected to actively participate in discussions. Missed sessions may be replaced by written tasks adapted to the situation.
Examination 1. One student-led presentation and discussion with chosen student partner
Teams of two students each will be assigned a current journal article with an emphasis in molecular endocrinology to present to the rest of the class. All articles will be read by the students prior to the presentation. Each team will be assigned a faculty member who will supervise their preparation and understanding of the article to be presented at an assigned date during class. Each team will make a formal presentation on the article and will review, critique and discuss alternative interpretations of the article. (Learning outcomes 4, 6, 7, and 9)

2. one written peer evaluation report
Each student will be assigned one team led presentation to critique both presenters and journal article. The critique will be formulated in a grant style format. The student will be expected to review the specific topic within molecular endocrinology that the article emphasizes. Then create a testable question and develop a hypothesis based on the topic. Then develop a methodological approach to prove the hypothesis. The student teams that present the article will be considered experts in that topic and the student will critique their position with in the field. (Learning outcomes 4, 6, 7, and 8)

3. one final exam
The final written exam will assess the fundimental principles in the following learning outcomes 1, 2, 3, and 5.

Literature and other teaching material Textbooks
1. Molecular Endocrinology, Editor Patricia Joseph-Bravo, 2006, Research Signpost.
2. Molecular Endocrinology 3rd Edition, Editior Franklyn F. Bolander, 2005, Elsevier Academic Press.
Only specific chapters will be used from each textbook.
Research Article: articles will be provided to students prior to course start date.
Course responsible John Flanagan
Institutionen för laboratoriemedicin
0704816995

john.flanagan@ki.se

CMM, L8:01
Andrology and Molecular Endocrinology Units
171 76
Solna
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