Kursplansdatabas för forskarutbildningskurser
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Kursplansdatabas för forskarutbildningskurser
KURSPLANER FÖR FORSKARUTBILDNINGSKURSER
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Svensk benämning | Apoptos: Teori och metoder |
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Engelsk benämning | Apoptosis: Theory and Methods |
Kursnummer | 1201 |
Antal högskolepoäng | 1.5 |
Kursansvarig institution | Institutet för miljömedicin |
Särskild behörighet | |
Betygsskala | Godkänd/Icke godkänd |
Fastställd av | The Board of Postgraduate Education |
Datum för fastställande | 2007-11-08 |
Kursens syfte | |
Kursens lärandemål | After the course the students will be able to use the knowledge of the principles, different mechanisms and methods currently guiding research in cell death (apoptosis). Since during the course all students will present and discuss their PhD projects, the obtained knowledge will help them to avoid methodological mistakes and develop their own projects. |
Kursens innehåll | Theoretical: The lectures will open with an introduction to cell death and an examination of the relative significance of apoptosis in biology and medicine. They will then discuss the latest results available on (i) molecular mechanisms of cell death, (ii) regulators of cell death and survival, (iii) role of different intracellular compartments in apoptosis, (iv) role of proteases in apoptosis, (v) phagocytosis in apoptosis, (vi) inducers of apoptosis, with particular emphasis on anti-cancer chemotherapy, (vii) inhibitors of apoptosis, with particular emphasis on therapeutic strategies for neurodegenerative disorders, (viii) apoptosis in immune system, (ix) relevance to toxicology, (x) oxidative stress and apoptosis, (xi) apoptosis and cell cycle regulation, (x) methods for detection of apoptosis. Practical: The students will work through 5 projects during the week. (1) Assessment of cell viability. (2) Assessment of apoptosis by examination of the nucleus (morphology, chromatin degradation). (3) Analysis of apoptosis by FACS. (4) Analysis of protease activation. (5) Analysis of mitochondrial changes |
Arbetsformer | Lectures, project work, laboratory work, discussions and presentations of students PhD projects. |
Obligatoriska moment | Lectures, project work and laboratory work are compulsory. If a student misses a compulsory part of the course, this can be completed at the next course occasion. |
Examination | Oral examination. |
Kurslitteratur och övriga läromedel | Compendium containing 17 essential articles and protocols for practical work | Kursansvarig |
Boris Zhivotovsky Institutet för miljömedicin 0852487588 0703297588 Boris.Zhivotovsky@ki.se Nobels väg. 13 17177 Stockholm |
Kontaktpersoner |
Boris Zhivotovsky Institutet för miljömedicin 0852487588 0703297588 Boris.Zhivotovsky@ki.se Nobels väg. 13 17177 Stockholm Charlotte Nilsson Institutet för miljömedicin charlotte.nilsson@ki.se |