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SYLLABI FOR DOCTORAL COURSES

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Swedish title Basal immunologi
English title Basic Immunology
Course number 5229
Credits 3.0
Responsible KI department Department of Medicine, Solna
Specific entry requirements Knowledge in basic cell biology.
Grading Passed /Not passed
Established by The Committee for Doctoral Education
Established 2020-02-25
Purpose of the course To give doctoral students the possibility to acquire a solid knowledge and understanding of fundamental principles in immunology.
All other courses in the doctoral education program Aii (Allergy, immunology and inflammation) assume that students have taken the Basic Immunology course, or otherwise have previously attained the same level of knowledge and understanding.
Intended learning outcomes To be able to:
- Explain the basic principles of innate and adaptive immunity and how different components of the immune system cooperate
- Describe and compare experimental aspects of immune-related diseases in a clinical perspective.
- Apply knowledge gained on the function of the immune system to write a research project proposal in immunology that will be discussed in pairs
- Review a chosen immunological/clinical topic, which will be presented as a group project
Contents of the course The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defense against infection, autoimmune and allergic diseases or transplantation.

Part 1: An overview of the immune system, T cells, B cells, Antigen presenting cells, Innate lymphoid cells, Innate vs adaptive immune responses.

Part 2: Immune defense against bacterial and viral infections, Primary immunodeficiencies, Autoimmune disease, Allergy, Vaccination, Clinical Immunology, Transplantation, Tumor Immunology. Questions and discussions. Presentation of projects.
Teaching and learning activities Lectures and seminars are given three days per week and remaining days are assigned for project work, a written assignment as well as reading. The project work and written assignment require studies between the two course parts, including meetings with mentors. On the last day of the course, the project work will be presented orally. An immunological quiz is connected to the different topics of the course, so that the student will be able to digest the relatively big material. The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts.
Compulsory elements All activities included in the course are compulsory. Absence needs to be compensated for in agreement with the course director.
Examination The student will be examined on both the project work and the written assignment. The project work will be evaluated by the group project mentor and by the course organisers during the oral presentations of the work. At this occasion special attention is given to all student´s active participation and contributions to the discussions. The individual written assignment is evaluated by the course organisers.
Literature and other teaching material Mandatory literature: Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai: Basic Immunology: Functions and Disorders of the Immune System. 6th edition. (Elsevier – Health Sciences Edition).
Lecture handouts uploaded to the course website. Scientific review articles proposed by group project mentors.
Course responsible Karine Chemin
Department of Medicine, Solna


karine.chemin@ki.se
Contact person