Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
Swedish title | Kliniska metodologier i metabol forskning |
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English title | Clinical methodologies in metabolic research |
Course number | 3153 |
Credits | 1.5 |
Responsible KI department | Department of Medicine, Huddinge |
Specific entry requirements | |
Grading | Passed /Not passed |
Established by | The Board of Doctoral Education |
Established | 2018-09-19 |
Purpose of the course | This course will enable the doctoral student to acquire and integrate knowledge of clinical and basic methodologies used in human metabolic research. It will promote understanding, competence, skills, judgement and approach in the field of obesity and diabetes mellitus and will facilitate student's development as future scientist, public health specialist and/or clinician in this field. |
Intended learning outcomes | After the course, students will have acquired a basic understanding of commonly used techniques in clinical and experimental metabolic research and an insight in how to combine analyses of clinical metabolic measurements with data obtained in molecular and cell culture-based methodologies. |
Contents of the course | The course is based on clinical metabolic studies in human subjects and in vitro studies of human cell metabolism. Students will receive a theoretical introduction to methodologies used in clinical and experimental metabolic research. In addition, they will get demonstrations of common clinical metabolic techniques including clamps, fat/muscle/liver biopsies, determination of body composition (by bioimpedance and DEXA) and arterial stiffness, continuous blood pressure and glucose monitoring, clinical questionnaires as well as assessments of physical activity and sleep quality. Some of the (non-invasive) methods will be practiced by the participants themselves. Students will also be introduced to and perform commonly used experimental techniques, such as gene expression analyses in clinical samples as well as metabolic measurements in cell cultures, e.g. insulin-stimulated glucose uptake and determination of lipid accumulation. Primary human cells will be used as a cell model. Students will be shown how clinical metabolic measures can be linked to results obtained in vitro and vice-versa. |
Teaching and learning activities | Lectures, group discussions, practical exercises, demonstrations, laboratory sessions. |
Compulsory elements | Practical exercises, demonstrations and laboratory sessions are compulsory and the absence must be compensated by written assays. |
Examination | Oral examination where students should describe how they could combine two of the methods they have learned during the week. |
Literature and other teaching material | 1. Metabolic regulation. A human perspective. Keith N.Frayn, - 3rd edition, 2010. ISBN 978-1-4051-8359-8 2. Protocols and lecture material will be given by the lecturers during the course. |
Course responsible |
Daniel P Andersson Department of Medicine, Huddinge Daniel.P.Andersson@ki.se |
Contact person |
Jurga Laurencikiene Department of Medicine, Huddinge Jurga.Laurencikiene@ki.se |