Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
Swedish title | Apoptos: Teori och metoder |
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English title | Apoptosis: Theory and Methods |
Course number | 3111 |
Credits | 1.5 |
Responsible KI department | Institutet för miljömedicin |
Specific entry requirements | |
Grading | Passed /Not passed |
Established by | The Board of Doctoral Education |
Established | 2018-08-09 |
Purpose of the course | The purpose of the course is to give doctoral students a basic understanding of the mechanisms of various cell death modalities (apoptosis, necrosis, autophagy), their role in pathogenesis of various disorders and methods that can be used in their detection. |
Intended learning outcomes | After the course the students will be able to use the knowledge of the principles, different mechanisms and methods currently guiding research in cell death (apoptosis). Since during the course all students will present and discuss their PhD projects, the obtained knowledge will help them to avoid methodological mistakes and develop their own projects. |
Contents of the course | Theoretical: The lectures will open with an introduction to cell death and an examination of the relative significance of apoptosis in biology and medicine. They will then discuss the latest results available on (i) molecular mechanisms of cell death, (ii) regulators of cell death and survival, (iii) role of different intracellular compartments in apoptosis, (iv) role of proteases in apoptosis, (v) phagocytosis in apoptosis, (vi) inducers of apoptosis, with particular emphasis on anti-cancer chemotherapy, (vii) inhibitors of apoptosis, with particular emphasis on therapeutic strategies for neurodegenerative disorders, (viii) apoptosis in immune system, (ix) relevance to toxicology, (x) oxidative stress and apoptosis, (xi) apoptosis and cell cycle regulation, (x) methods for detection of apoptosis. Practical: The students will work through 5 projects during the week. (1) Assessment of cell viability. (2) Assessment of apoptosis by examination of the nucleus (morphology, chromatin degradation). (3) Analysis of apoptosis by FACS. (4) Analysis of protease activation. (5) Analysis of mitochondrial changes |
Teaching and learning activities | Lectures, project work, laboratory work, discussions and presentations of students PhD projects. |
Compulsory elements | Lectures, project work and laboratory work are compulsory. If a student misses a compulsory part of the course, this can be completed at the next course occasion. |
Examination | Oral examination. |
Literature and other teaching material | Compendium containing 17 essential articles and protocols for practical work. | Course responsible |
Boris Zhivotovsky Institutet för miljömedicin 0852487588 0703297588 Boris.Zhivotovsky@ki.se Nobels väg. 13 17177 Stockholm |
Contact person |
Johanna Bergman Institutet för miljömedicin johanna.bergman@ki.se Nobels väg 13 17177 Stockholm |