Kursplansdatabas för forskarutbildningskurser
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Kursplansdatabas för forskarutbildningskurser
KURSPLANER FÖR FORSKARUTBILDNINGSKURSER
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| Svensk benämning | Cancercellens metabolism |
|---|---|
| Engelsk benämning | Cancer Cell Metabolism |
| Kursnummer | 3076 |
| Antal högskolepoäng | 1.5 |
| Kursansvarig institution | Institutionen för mikrobiologi, tumör- och cellbiologi |
| Särskild behörighet | Basic knowledge in Tumor Cell Biology |
| Betygsskala | Godkänd/Icke godkänd |
| Fastställd av | The Board of Doctoral Education |
| Datum för fastställande | 2018-03-20 |
| Kursens syfte | The course provides an introduction to cancer cell metabolism. Focus is on the roles of oncogenic signaling and tumor microenvironment as drivers of tumor development and progression. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed. |
| Kursens lärandemål | After the course, the student should be able to:
- describe and explain the role of altered cellular metabolism in cancer development and cancer progression; - reflect upon the interaction between oncogenic signaling and tumor metabolism; - discuss how tumor metabolism may be exploited in anticancer therapies and diagnosis/prognosis. |
| Kursens innehåll | Overview about cell metabolism
The major metabolic pathways The mitochondrion Signalling pathways and metabolic control Cancer cell metabolism Methods to study cell metabolism Targeting metabolism for cancer treatment |
| Arbetsformer | The course consists of lectures with invited national and international scientists with focus on Cancer cell Metabolism. The students will actively talk to the scientists in the ""Meet the Scientists"" format and discuss the topics during beehive discussions. The course is given full-time during 1 week. The teaching is mainly in lecture/seminar form and also includes project work. This project is presented orally on the last day of the course. The project work requires studies of a specific topic in Cancer Cell Metabolism.
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| Obligatoriska moment | Attendance at lectures is strongly advised. Participation in the beehive and ""Meet the scientists"" session is mandatory. To compensate for absence due to e.g. illness the student may be required to write a report and/or discuss the missed subject with the course leaders. |
| Examination | Examination is divided into two parts: Firstly, during active participation in the ""Meet the scientists"" seminar and in connection with the beehive group discussion. Secondly, the students will be given an assignment to be presented on the last day of the course. This assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an overview of the field which motivates a specific research question identified by the student/s and a brief work plan that explains how the question/hypothesis can be solved/investigated. |
| Kurslitteratur och övriga läromedel | Literature suggestions will be made by the lecturers during the course. In addition, this is a list of suggested literature Cairns RA, Harris IS, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011 Schulze A and Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012 Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012 Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov 2013 Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 2013 | Kursansvarig |
Marie Arsenian-Henriksson Institutionen för mikrobiologi, tumör- och cellbiologi Marie.Arsenian.Henriksson@ki.se |
| Kontaktpersoner |
Judit Liano Pons Institutionen för mikrobiologi, tumör- och cellbiologi judit.liano.pons@ki.se |
