Kursplansdatabas för forskarutbildningskurser
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Kursplansdatabas för forskarutbildningskurser
KURSPLANER FÖR FORSKARUTBILDNINGSKURSER
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| Svensk benämning | Immunogenicitet: Immunreaktioner mot biologiska läkemedel |
|---|---|
| Engelsk benämning | Immunogenicity: Immune responses against biological drugs |
| Kursnummer | 3067 |
| Antal högskolepoäng | 1.5 |
| Kursansvarig institution | Institutionen för klinisk neurovetenskap |
| Särskild behörighet | |
| Betygsskala | Godkänd/Icke godkänd |
| Fastställd av | The Board of Doctoral Education |
| Datum för fastställande | 2019-01-14 |
| Kursens syfte | Understanding of central terms and definitions in the field of immunogenicity, used in research and in clinical applications. To become familiar with the identified molecular and cellular immunological processes that trigger and increase the risk for developing anti-drug antibodies (ADA). Understanding of how immunogenicity needs to be taken into consideration all the way from choosing your biological target of treatment, to drug development, approval, clinical routine and individualized therapy and health care practice. |
| Kursens lärandemål | At the end of the course the student should be able to: - Understand what determines the immunogenicity of drugs and why they differ in this respect. - Give examples of different methods of how to measure drug level and ADA. - Understand the algorithms needed in clinical practice and what consequences ADA might have for treatment decision, safety and efficacy. - Integrate this knowledge in your own research project or a disease and treatment of choice. |
| Kursens innehåll | The course will give you an orientation of the clinical research fields where treatment with biopharmaceuticals are important and how the immune system can react against different biopharmaceuticals. It will include the diseases MS, RA, IBD, and SLE and biopharmaceuticals like IFNbeta, natalizumab, rituximab, TNF-blockers as well as the biosimilars for these. A range of immunoassay methodologies that can be used to measure drug levels and ADA will be presented and the clinical relevance of the test results discussed. The course will also give insights on the type of research being done to identify risk factors for ADA, and optimisation of drug design, production and administration to minimize the risk. Ways to improve treatment regiments adopted to results of drug level and ADA, as well how to monitor and store data in clinical routine will be discussed. |
| Arbetsformer | Lectures, individual essays, peer-review and oral presentation. |
| Obligatoriska moment | Lectures, essay, peer-review and oral presentation. Absence from lectures can be compensated for by writing an additional essay on the subject missed. |
| Examination | Essay, peer-review and oral presentation. |
| Kurslitteratur och övriga läromedel | Articles selected by the teachers and by own literature search in PubMed or other data bases. | Kursansvarig |
Anna Fogdell-Hahn Institutionen för klinisk neurovetenskap 0705-449060 Anna.Fogdell-Hahn@ki.se CMM Solna |
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