Kursplansdatabas för forskarutbildningskurser
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Kursplansdatabas för forskarutbildningskurser
KURSPLANER FÖR FORSKARUTBILDNINGSKURSER
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| Svensk benämning | Icke kovalenta interaktioner i proteiner |
|---|---|
| Engelsk benämning | Non-covalent interactions in proteins |
| Kursnummer | 1441 |
| Antal högskolepoäng | 7.5 |
| Kursansvarig institution | Institutionen för biovetenskaper och näringslära |
| Särskild behörighet | Basic knowledge in chemistry or physics from university. |
| Betygsskala | Godkänd/Icke godkänd |
| Fastställd av | The Board of Postgraduate Education |
| Datum för fastställande | 2007-02-08 |
| Kursens syfte | |
| Kursens lärandemål | After the course, the students should have reached correct understanding of the physical basis of the different types of non-covalent interactions and their role in functional properties of protein. Furthermore, the students should have acquired to capacity to correctly devise an experimental strategy within their own research subject and to correctly interpreting experimental results relevant to the topic. |
| Kursens innehåll | Van der Waals interactions Hydrogen bonds Hydrophobic interactions Packing density of proteins, molecular volume Debye - Hückel theory Desolvation energy, Born theory Calculation of the electrostatic interactions in proteins Ionisation equilibria Protonation/deprotonation equilibria in proteins Application of the theory of electrostatic interactions Denatured proteins pH stability of proteins Thermal denaturation Interrelation between non-covalent interactions Thermodynamics of proteins, experiments, interpretations The analysis of non-covalent interactions for drug design |
| Arbetsformer | Lectures by invited speakers, home works, seminars and roundtable discussions |
| Obligatoriska moment | |
| Examination | Written exam: three tasks should be solved, solutions should be defended. |
| Kurslitteratur och övriga läromedel | Non-covalent interactions in proteins, Karshikoff A, 2006, Imperial College Press, London. Biophysical Chemistry, Cantor & Schimmel, 1980 Freeman & Co, NY |
Kursansvarig |
Alessandra Villa Institutionen för biovetenskaper och näringslära +46-8-524 81081 Alessandra.Villa@ki.se Hälsovägen 5 NEO 141 83 Huddingen |
| Kontaktpersoner |
