Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Icke kovalenta interaktioner i proteiner |
|---|---|
| English title | Non-covalent interactions in proteins |
| Course number | 1441 |
| Credits | 7.5 |
| Responsible KI department | Department of Biosciences and Nutrition |
| Specific entry requirements | Basic knowledge in chemistry or physics from university. |
| Grading | Passed /Not passed |
| Established by | The Board of Postgraduate Education |
| Established | 2007-02-08 |
| Purpose of the course | |
| Intended learning outcomes | After the course, the students should have reached correct understanding of the physical basis of the different types of non-covalent interactions and their role in functional properties of protein. Furthermore, the students should have acquired to capacity to correctly devise an experimental strategy within their own research subject and to correctly interpreting experimental results relevant to the topic. |
| Contents of the course | Van der Waals interactions Hydrogen bonds Hydrophobic interactions Packing density of proteins, molecular volume Debye - Hückel theory Desolvation energy, Born theory Calculation of the electrostatic interactions in proteins Ionisation equilibria Protonation/deprotonation equilibria in proteins Application of the theory of electrostatic interactions Denatured proteins pH stability of proteins Thermal denaturation Interrelation between non-covalent interactions Thermodynamics of proteins, experiments, interpretations The analysis of non-covalent interactions for drug design |
| Teaching and learning activities | Lectures by invited speakers, home works, seminars and roundtable discussions |
| Compulsory elements | |
| Examination | Written exam: three tasks should be solved, solutions should be defended. |
| Literature and other teaching material | Non-covalent interactions in proteins, Karshikoff A, 2006, Imperial College Press, London. Biophysical Chemistry, Cantor & Schimmel, 1980 Freeman & Co, NY |
Course responsible |
Alessandra Villa Department of Biosciences and Nutrition +46-8-524 81081 Alessandra.Villa@ki.se Hälsovägen 5 NEO 141 83 Huddingen |
| Contact person |
