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Svensk benämning	Baskurs i molekylär avbildning inom medicinsk diagnostik genom användning av magnetresonansfysik
Engelsk benämning	Basic principles in molecular imaging for medical diagnostics through magnetic resonance physics
Kursnummer	2568
Antal högskolepoäng	3.0
Kursansvarig institution	Institutionen för onkologi-patologi
Särskild behörighet
Betygsskala	Godkänd/Icke godkänd
Fastställd av	The Board of Doctoral Education
Datum för fastställande	2017-03-14
Kursens syfte	This course will provide the student with an appreciation of how improvements in the current data interpretation of Magnetic Resonance Spectroscopy (MRS) and MR spectroscopic imaging (MRSI) can enhance the resolution and diagnostic accuracy, and thus better detect and correctly diagnose early cancers and other major illnesses. The student, including the clinician and clinical researcher, is invited to join in the exploration of what mathematical advances in signal processing could offer for molecular imaging through MRS and MRSI.
Kursens lärandemål	--To understand the basic principles of magnetic resonance (MR) and how these are implemented in magnetic resonance imaging and spectroscopy --To distinguish between anatomic and molecular imaging through MR. --To be able to interpret an MR spectrum, in general terms. --To be able to explain why mathematics are essential for processing of MR signals. --To be able to conceptualize and generate new ways of thinking about the possibilities offered by more advanced mathematical approaches for processing MR signals, and how these could potentially impact upon medical diagnostics.
Kursens innehåll	The basic principles of magnetic resonance physics, as these apply to Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) are presented. We review how biological signals are processed with data analytical techniques in current practice, the limitations of these techniques as they impact upon clinical diagnostics and the potential impact of new analytical methods for improving detection of malignant and other pathological processes. 1. Introductory lecture: Molecular imaging through MR physics/an overview 2. Basic principles of magnetic resonance imaging and magnetic resonance spectroscopy (MRS). 3. Fundamentals of signal processing for medical applications 4. Magnetic resonance spectroscopic imaging (MRSI), safety considerations in MR. 5. Review and future perspectives: Advances in signal processing for MR physics
Arbetsformer	The basis of the Course is lectures in which the students should strive to actively participate with questions and comments. Handouts of each lecture with ample space for note taking will be provided. Each lecture will be accompanied by homework which the students should prepare and to which they will receive detailed feedback. Group work is encouraged, as long as each student ensures that he/she has thoroughly and completely grasped all the material. There will be one open afternoon per week during which students can meet with the teachers to ask questions and explore areas of interest. Before the examination there will be a practice oral examination for each student to test his/her knowledge and receive feedback from the teachers. It is our experience that students who attend all the lectures, complete the reading and homework, actively participate and attend the practice oral examination will be able to handle the examination in a satisfactory manner.
Obligatoriska moment	It is vital that the students attend all the lectures and complete the homework. If the student has a valid reason for an absence, he/she will need to complete the reading for the lecture, turn in the homework and then come to the open afternoon for review and feedback.
Examination	The examination is written, closed-book. It is our experience that students who attend all the lectures, complete the reading and homework, actively participate and attend the practice oral examination will be able to handle the examination in a satisfactory manner.
Kurslitteratur och övriga läromedel	Belkic Dz. Quantum Mechanical Signal Processing and Spectral Analysis, Institute of Physics Publishing, Bristol, (2004). Belkic K. Molecular Imaging through Magnetic Resonance for Clinical Oncology, Cambridge International Science Publishing, Cambridge (2004). Belkic Dz, Belkic K. Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications, CRC Press Taylor & Francis Group, London (2010). McRobbie DW, Moore EA, Graves MJ, Prince MR. MRI from picture to proton, Cambridge University Press, Cambridge (2003)
Kursansvarig	Karen Belkic Institutionen för onkologi-patologi Karen.Belkic@ki.se Karolinska Institutet Helicopter Bldg P9 PO Box 260 17177 Stockholm
Kontaktpersoner	Karen Belkic Institutionen för onkologi-patologi Karen.Belkic@ki.se Karolinska Institutet Helicopter Bldg P9 PO Box 260 17177 Stockholm

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