Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Antigen-presentation och T-cellsaktivering |
|---|---|
| English title | Antigen presentation and T cell activation |
| Course number | 2363 |
| Credits | 1.5 |
| Responsible KI department | Institutionen för onkologi-patologi |
| Specific entry requirements | Basic immunology course, or otherwise have attained the same level of previous knowledge. |
| Grading | Passed /Not passed |
| Established by | The Board of Doctoral Education |
| Established | 2016-03-17 |
| Purpose of the course | This course will provide a cutting edge overview of antigen presentation and T cell activation. This course is suitable for PhD students who want to deepen their knowledge in important aspects of various lymphocyte subsets biology. Students will also learn about new techniques such as lymphocyte visualization and functional assays that could be beneficial for their own research projects. |
| Intended learning outcomes | By completing this course the students will be able to account for different types of antigen capture and processing, antigen presentation pathways (MHC class I and II), the CD1 system, peptide/lipid/glycolipid presentation, immune evasion of antigen presentation in terms of processing and presentation on cell surface and altered peptide ligands, as well as in terms of some microbial dissemination strategies. Students will also be able to demonstrate that they have acquired the required knowledge about T lymphocyte recognition of antigen-presentation with strong focus on lymphocyte and target cell apoptosis/survival signaling pathways within the cells. The students will also be able to demonstrate that they have acquired the required knowledge about T cell activation and the effects of this at specific situations such as after stem cell or organ transplantation as well as mechanisms behind T cell mediated Autoimmunity. |
| Contents of the course | Course Syllabus, Review articles and specific papers related to the lectures are distributed prior to the course. The following will be covered during the course. Antigen capture (including endocytosis, phagocytosis) and some immune evasion strategies related to this. This will be followed by a thorough walk-through of the antigen presentation pathways, both MHC class I and II. Terms like altered peptide ligands, cross presentation, TCR recognition, allogeneic T cell activation, and NK cell receptors will be covered. After this microbial immune evasion targeting antigen presentation pathways will be discussed and presented. The CD1 system, presentation of lipids, glycolipids (including microbial interference, presentation to lymphocytes such as CD1 restricted T cells and NKT Cells, lymphocyte mediated regulation of antigen presentation) will also be discussed. It will be finished off by covering T cell activation and its effect after stem cell and organ transplantation and T cell mediated autoimmunity: Results of antigen presentation to effector cells, with focus on T lymphocyte and target cell apoptosis and survival; signaling pathways and network within the cells. Ending with a written exam and a small group work. |
| Teaching and learning activities | The course will be based on lectures, as well as extra time for follow up discussions. In addition a smaller group work will enable the students to gain deeper knowledge in a small area of interest. The students are also given literature (see below) in order to prepare for the lectures and discussions. |
| Compulsory elements | All lectures and group sessions are considered mandatory. Missed events should be compensated for with a written report on the subject in accordance with the indications of the course organizer. |
| Examination | To pass the course, the student has to show that the learning outcomes have been reached. The students will be assessed with a group project presented in a written report, along with individual oral presentations. The focus of the examination is gain of knowledge rather than test of knowledge. |
| Literature and other teaching material | Lecture notes, review articles and selected articles relevant to the lectures (invited speakers will also be asked to suggest papers), including these examples: - T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol. 2015;33:169-200. Rossjohn et al.; - The burgeoning family of unconventional T cells. Nat Immunol. 2015 Nov;16(11):1114-23.Godfrey DI et al.; - Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61.Malissen B. |
Course responsible |
Sarah Thunberg Institutionen för onkologi-patologi sarah.thunberg@ki.se |
| Contact person |
Isabelle Magalhaes Institutionen för klinisk vetenskap, intervention och teknik 0739752974 Isabelle.Magalhaes@ki.se |
