Kursplansdatabas för forskarutbildningskurser
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Kursplansdatabas för forskarutbildningskurser
KURSPLANER FÖR FORSKARUTBILDNINGSKURSER
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| Svensk benämning | Genetisk epidemiologi |
|---|---|
| Engelsk benämning | Genetic epidemiology |
| Kursnummer | 2228 |
| Antal högskolepoäng | 1.5 |
| Kursansvarig institution | Institutionen för medicinsk epidemiologi och biostatistik |
| Särskild behörighet | Knowledge in epidemiology and biostatistics equivalent to ""Epidemiology I: Introduction to epidemiology"", ""Epidemiology II: Design of epidemiological studies"", ""Biostatistics I: Introduction for epidemiologists"" and ""Biostatistics II: Logistic regression for epidemiologists"". |
| Betygsskala | Godkänd/Icke godkänd |
| Fastställd av | The Board of Doctoral Education |
| Datum för fastställande | 2016-03-22 |
| Kursens syfte | The course focuses on concepts and methods used in studies of genetic variation influencing disease and other phenotypes. |
| Kursens lärandemål | After successfully completing this course you are expected to be able to: -Describe the basic organization of the human genome and the central dogma of eukaryote genetics. -Relate the concepts of meiosis, recombination, linkage and linkage disequilibrium to each other. -Draw conclusions about genetic influences from trait distributions in families and estimate the relative degree of genetic influences from twin correlation data. -Use publically available databases to find positions of genetic markers and to identify suitable tag markers for candidate genes. -Utilize SNP markers as instrumental variables and polygenic predictors. Intended learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation (Bloom, 1956, extended by Anderson and Krathwohl, 2001). |
| Kursens innehåll | The course is about concepts and methods used in studies of genetic variation influencing disease and other phenotypes. It will thoroughly cover basic genetic inheritance and how it influences complex and quantitative traits. Modern gene-discovery strategies and polygenic methods will be described in theory and practice. The primary focus is on genetic association studies with study design and interpretation/utilization of results. Mendelian randomization approaches. Secondary focus will be on the role of de novo mutations and epigenetic mechanisms for complex traits. |
| Arbetsformer | Lectures, computer lab, group seminars. |
| Obligatoriska moment | The individual examination (summative assessment) is compulsory. |
| Examination | To pass the course, the student has to show that the learning outcomes have been achieved. One individual assessment of the learning outcomes consists of an individual written home examination (summative assessment), which students have one week to complete after the course ends. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. |
| Kurslitteratur och övriga läromedel | Recommended reading: Compendium covering basic genetic concepts will be distributed before the course. Scientific articles and hand-outs distributed during the course. |
Kursansvarig |
Sara Hägg Institutionen för medicinsk epidemiologi och biostatistik Sara.Hagg@ki.se |
| Kontaktpersoner |
Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08-524 822 93 gunilla.nilsson.roos@ki.se |
