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SYLLABI FOR DOCTORAL COURSES

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Swedish title Basal immunologi
English title Basic immunology
Course number 2302
Credits 3.0
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2016-03-22
Purpose of the course The purpose is to give doctoral students lacking a solid knowledge and understanding of fundamental principles in immunology the possibility to obtain this through a high quality basic course. All other courses in the Doctoral education programme Aii (Allergy, immunology and inflammation) assume that students have taken the Basic Immunology course, or otherwise have attained the same level of previous knowledge and understanding.
Intended learning outcomes To understand basic principles of innate and adaptive immunity and how different components of the immune system cooperate.
To be able to relate, compare and understand experimental aspects of immune-related disease in a clinical perspective.
To adapt knowledge gained of the function of the immune system by being able to analyze and discuss an immunological/clinical case (group project).
To present the group project and discuss the results as well as work in pairs with clinical cases.
Contents of the course The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmune and allergic disease or transplantation.

Part 1:
Introduction
An overview of the immune system
T cells
B cells
Antigen-presenting cells
Innate vs adaptive immune responses

Part 2:
Immune defence against bacterial and viral infections
Primary immunodeficiencies
Autoimmune disease
Allergy
Vaccination
Clinical Immunology
Transplantation
Tumour Immunology
Questions and discussions
Presentation of projects.
Teaching and learning activities The course is given full-time during a total of six days separated into two parts. The teaching is mainly in lecture/seminar form but also includes project work in small groups, as well as a written assignment. The group projects are then presented orally on the last day of the course. The project work and written assignment require studies between the two course parts, including meetings with mentors. Course literature (Abbas) is handed out at the course start. An immunological quiz is connected to the different chapters in the book so that the student will be able to digest the relatively big material.
The course is designed so that clinically active doctors will be better able to combine it with work in the clinic (Mondays and Fridays contain no scheduled course work) .The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts. Considering the substantial literature requirement plus the written assignment and project work, we estimate that an extra 32h of study is needed, which is not included in the schedule.
Compulsory elements Discussion sessions, group project work and participation at the project presentation is compulsory as well as work with the written assignment. In the case of absence a separate occasion is organized with presentation for the course organizers.

Examination Evaluation by the group project mentor and oral presentations of small-group project work. At this occasion special attention is given to that all students are actively participating. The written assignment is evaluated by the course organizers and - with respect to proposing new research ideas related to the students´own PhD projects - by their supervisors.
Literature and other teaching material Abul Abbas and Andrew Lichtman: Basic Immunology. (Saunders Elsevier). The book is free and is handed out at the course start. Lecture handouts uploaded to the course website. Scientific review articles proposed by group project mentors.
Course responsible Johan Öckinger
Institutionen för medicin, Solna
0851770663
0702884481
Johan.Ockinger@ki.se

Contact person Mikael Karlsson
Institutionen för mikrobiologi, tumör- och cellbiologi


Mikael.Karlsson@ki.se